Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.36 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.36 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.36 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.36 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.36 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29850315 | 0.86 | KDM4E (0.70) | KDM4EALDH1A1SMN1; SMN2MAPK1POLB | |
| SCHEMBL21906404 | 0.86 | KDM4E (0.70) | KDM4EALDH1A1SMN1; SMN2MAPK1POLB | |
| SCHEMBL30003417 | 0.84 | KDM4E (0.74) | KDM4EALDH1A1SMN1; SMN2MAPK1POLB | |
| SCHEMBL14349080 | 0.84 | KDM4E (0.74) | KDM4EALDH1A1SMN1; SMN2MAPK1POLB | |
| SCHEMBL20680057 | 0.82 | KDM4E (0.64) | KDM4EALDH1A1SMN1; SMN2MAPK1POLB | |
| SCHEMBL8164304 | 0.80 | MEN1 (0.37) | KDM4EALDH1A1SMN1; SMN2MAPK1POLB | |
| SCHEMBL8166408 | 0.80 | MEN1 (0.37) | KDM4EALDH1A1SMN1; SMN2MAPK1POLB | |
| SCHEMBL8026149 | 0.80 | KDM4E (0.61) | KDM4EALDH1A1SMN1; SMN2MAPK1POLB | |
| SCHEMBL17189587 | 0.79 | KDM4E (0.75) | KDM4EALDH1A1SMN1; SMN2MAPK1POLB | |
| SCHEMBL22788818 | 0.79 | KDM4E (0.67) | KDM4EALDH1A1SMN1; SMN2MAPK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140121238-A1 | TOTAL SYNTHESIS OF REDOX-ACTIVE 1.4-NAPHTHOQUINONES AND THEIR METABOLITES AND THEIR THERAPEUTIC USE AS ANTIMALARIAL AND SCHISTOMICIDAL AGENTS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2014-05-01 | — | — | US | claimed |
| EP-2691372-A1 | TOTAL SYNTHESIS OF REDOX-ACTIVE 1.4-NAPHTHOQUINONES AND THEIR METABOLITES AND THEIR THERAPEUTIC USE AS ANTIMALARIAL AND SCHISTOMICIDAL AGENTS | Centre National De La Recherche Scientifique (FR) | 2014-02-05 | — | — | EP | claimed |
| WO-2012131010-A1 | TOTAL SYNTHESIS OF REDOX-ACTIVE 1.4-NAPHTHOQUINONES AND THEIR METABOLITES AND THEIR THERAPEUTIC USE AS ANTIMALARIAL AND SCHISTOMICIDAL AGENTS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2012-10-04 | — | — | WO | claimed |
| EP-2505583-A1 | Total synthesis of redox-active 1.4-naphthoquinones and their metabolites and their therapeutic use as antimalarial and schistomicidal agents | Centre National de la Recherche Scientifique (FR) | 2012-10-03 | — | — | EP | claimed |
| WO-2021125905-A1 | NOVEL THIAZOLE DERIVATIVE AND USE THEREOF | 가천대학교 산학협력단 | 2021-06-24 | — | — | WO | disclosed |
| EP-3018116-B1 | VITAMIN K2 INTERMEDIATES | KAPPA BIOSCIENCE AS (NO) | 2020-10-28 | — | — | EP | disclosed |
| EP-3018116-B1 | VITAMIN K2 INTERMEDIATES | KAPPA BIOSCIENCE AS (NO) | 2020-10-28 | — | — | EP | disclosed |
| US-10472314-B2 | Process for the preparation of vitamin K2 | KAPPA BIOSCIENCE AS (NO) | 2019-11-12 | — | — | US | disclosed |
| US-10472314-B2 | Process for the preparation of vitamin K2 | KAPPA BIOSCIENCE AS (NO) | 2019-11-12 | — | — | US | disclosed |
| EP-2691372-B1 | TOTAL SYNTHESIS OF REDOX-ACTIVE 1.4-NAPHTHOQUINONES AND THEIR METABOLITES AND THEIR THERAPEUTIC USE AS ANTIMALARIAL AND SCHISTOMICIDAL AGENTS | CENTRE NAT RECH SCIENT (FR) | 2019-10-16 | — | — | EP | disclosed |
| US-20170283354-A1 | PROCESS FOR THE PREPARATION OF VITAMIN K2 | KAPPA BIOSCIENCE AS (NO) | 2017-10-05 | — | — | US | disclosed |
| US-20170283354-A1 | PROCESS FOR THE PREPARATION OF VITAMIN K2 | KAPPA BIOSCIENCE AS (NO) | 2017-10-05 | — | — | US | disclosed |
| US-5229385-A | Thromboxane A2 and lipoxygenase inhibitors | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-07-20 | — | — | US | disclosed |
| US-5106858-A | For disfunction of heart, brain, lung or kidney | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-04-21 | — | — | US | disclosed |
| EP-0234729-B1 | QUINONE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1991-12-27 | — | — | EP | disclosed |
| US-4985447-A | USEFUL FOR TREATMENT AND PREVENTION OF DISEASES DUE TO DYSFUNCTION OF HEART, BRAIN, LUNG AND KIDNEY | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1991-01-15 | — | — | US | disclosed |
| US-4851413-A | TREATMENT OF HEART, BRAIN, LUNG OR KIDNEY DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1989-07-25 | — | — | US | disclosed |
| US-4234746-A | Metallo-substituted naphthalene | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1980-11-18 | — | — | US | disclosed |
| US-4159993-A | 3-Metallo substituted naphthalenes | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1979-07-03 | — | — | US | disclosed |
| US-4089873-A | Preparation of menaquinones | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1978-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10472314-B2 | Process for the preparation of vitamin K2 | PROC, VKORC1, VKORC1L1 | KDM4E 253/4885ALDH1A1 536/4885SMN1; SMN2 1923/4885 |
| US-20170283354-A1 | PROCESS FOR THE PREPARATION OF VITAMIN K2 | PROC, VKORC1, VKORC1L1 | KDM4E 249/4885ALDH1A1 415/4885SMN1; SMN2 2036/4885 |
| US-20140121238-A1 | TOTAL SYNTHESIS OF REDOX-ACTIVE 1.4-NAPHTHOQUINONES AND THEIR METABOLITES AND THEIR THERAPEUTIC USE AS ANTIMALARIAL AND SCHISTOMICIDAL AGENTS | NQO1, AOX1, CYP4X1 | KDM4E 1489/4885ALDH1A1 293/4885SMN1; SMN2 2809/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.