Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.30 |
| ▸ | HPGDS | O60760 | 1/20 | 0.30 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.30 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.30 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.30 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.30 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.30 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.30 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15075626 | 0.83 | HDAC1 (0.41) | HDAC1HDAC6KDM4EADRA2AADRA2B | |
| SCHEMBL13536643 | 0.79 | HDAC1 (0.42) | HDAC1HDAC6HPGDKDM4EADRA2A | |
| SCHEMBL13459312 | 0.74 | KDM4E (0.41) | HDAC1HDAC6KDM4EKMT2AELANE | |
| SCHEMBL13459606 | 0.74 | HDAC1 (0.46) | HDAC1HDAC6HPGDKDM4EADRA2A | |
| SCHEMBL5483761 | 0.73 | HPGD (0.58) | HPGDKDM4EKMT2A | |
| SCHEMBL24782533 | 0.69 | HDAC1 (0.38) | HDAC1HDAC6KDM4EADRA2AADRA2B | |
| SCHEMBL4400946 | 0.67 | KCNA5 (0.40) | HDAC1HDAC6 | |
| SCHEMBL780147 | 0.66 | CA2 (0.50) | KMT2A | |
| SCHEMBL15075594 | 0.65 | TSHR (0.41) | HDAC1HDAC6HPGDKDM4EKMT2A | |
| SCHEMBL1711802 | 0.65 | HDAC1 (0.37) | HDAC1HDAC6KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130165452-A1 | Substituted Heteroaryls | PFIZER INC. (US) | 2013-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165452-A1 | Substituted Heteroaryls | GCKR, GCK, GALK1 | HDAC1 467/4885HDAC6 938/4885HPGD 2200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.