Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.35 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.35 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.35 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.35 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.35 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.35 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15075626 | 0.80 | HDAC1 (0.41) | HDAC1HDAC6TSHRLMNATDP1 | |
| SCHEMBL13536643 | 0.80 | HDAC1 (0.42) | HDAC1HDAC6TSHRLMNAADRA2A | |
| SCHEMBL25169259 | 0.77 | CA2 (0.42) | HDAC6TSHRLMNAALDH1A1TDP1 | |
| SCHEMBL8607426 | 0.76 | CA2 (0.41) | TSHRLMNAALDH1A1TDP1CA2 | |
| SCHEMBL4400946 | 0.75 | KCNA5 (0.40) | HDAC1HDAC6 | |
| SCHEMBL15075596 | 0.74 | HDAC1 (0.38) | HDAC1HDAC6ADRA2AADRA2BADRA2C | |
| SCHEMBL28101005 | 0.74 | NNMT (0.49) | LMNAALDH1A1KDM4ESMN1; SMN2KMT2A | |
| SCHEMBL24782533 | 0.74 | HDAC1 (0.38) | HDAC1HDAC6LMNAALDH1A1ADRA2A | |
| SCHEMBL13459312 | 0.71 | KDM4E (0.41) | HDAC1HDAC6TDP1CA2CA4 | |
| SCHEMBL25221122 | 0.69 | KCNQ3 (0.39) | CA2CA4CA5AKCNQ3KCNQ2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010029461-A1 | HETEROARYLS AMIDE DERIVATIVES AND THEIR USE AS GLUCOKINASE ACTIVATORS | PFIZER INC. (US) | 2010-03-18 | — | — | WO | disclosed |