Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 9/20 | 0.89 |
| ▸ | MAPK12 | P53778 | 9/20 | 0.89 |
| ▸ | MAPK11 | Q15759 | 9/20 | 0.89 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.89 |
| ▸ | RAF1 | P04049 | 4/20 | 0.89 |
| ▸ | GCGR | P47871 | 5/20 | 0.87 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.87 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.74 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 3/20 | 0.67 |
| ▸ | TP53 | P04637 | 2/20 | 0.67 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.66 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.66 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.66 |
| ▸ | FRK | P42685 | 1/20 | 0.66 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.66 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.66 |
| ▸ | GSK3B | P49841 | 1/20 | 0.66 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.66 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6469341 | 0.94 | MAPK13 (1.00) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL6469323 | 0.93 | MAPK13 (0.79) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL6164173 | 0.93 | MAPK13 (0.79) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL2648503 | 0.93 | MAPK11 (1.00) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL8008805 | 0.92 | NOX1 (0.85) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL15400824 | 0.92 | NOX1 (0.85) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL8388860 | 0.92 | MAPK13 (0.77) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL3455232 | 0.87 | NOX1 (0.77) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL8104080 | 0.86 | MAPK13 (0.86) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL1308320 | 0.86 | MAPK13 (0.86) | MAPK13MAPK12MAPK11MAPK14RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130165472-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165472-A1 | HETEROARYLS AND USES THEREOF | PIK3R4, VPS4B, PIK3C2A | MAPK13 1623/4885MAPK12 2139/4885MAPK11 1839/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.