Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 6/20 | 0.86 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.86 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.86 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.86 |
| ▸ | MAPT | P10636 | 5/20 | 0.86 |
| ▸ | RAF1 | P04049 | 4/20 | 0.86 |
| ▸ | TP53 | P04637 | 3/20 | 0.86 |
| ▸ | MEN1 | O00255 | 3/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.80 |
| ▸ | HPGD | P15428 | 2/20 | 0.80 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.80 |
| ▸ | GLA | P06280 | 1/20 | 0.80 |
| ▸ | GAA | P10253 | 1/20 | 0.80 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.80 |
| ▸ | GFER | P55789 | 1/20 | 0.80 |
| ▸ | NOX1 | Q9Y5S8 | 3/20 | 0.76 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | HTT | P42858 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15400046 | 1.00 | MAPK13 (0.86) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL1308320 | 1.00 | MAPK13 (0.86) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL1132001 | 1.00 | MAPK13 (0.86) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL15400824 | 0.94 | NOX1 (0.85) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL8008805 | 0.94 | NOX1 (0.85) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL6469341 | 0.93 | MAPK13 (1.00) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL17133350 | 0.91 | MAPT (0.73) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL11923005 | 0.91 | MAPK13 (0.77) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL3455232 | 0.89 | NOX1 (0.77) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL15075610 | 0.88 | MAPK13 (0.77) | MAPK13MAPK12MAPK11MAPK14MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834723-B2 | Pentaarylbiimidazole compound and production method for said compound | KANTO KAGAKU KABUSHIKI KAISHA (JP) | 2017-12-05 | — | — | US | disclosed |
| US-20170130124-A1 | PENTAARYLBIIMIDAZOLE COMPOUND AND PRODUCTION METHOD FOR SAID COMPOUND | KANTO KAGAKU KABUSHIKI KAISHA (JP) | 2017-05-11 | — | — | US | disclosed |
| EP-0626969-B1 | CoA-IT AND PAF INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2000-05-24 | — | — | EP | disclosed |
| US-5663053-A | COENZYME A TRANSACYLASE FOR SCREENING | SMITHKLINE BEECHAM CORPORATION (US) | 1997-09-02 | — | — | US | disclosed |
| US-5648373-A | CoA-IT and PAF inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1997-07-15 | — | — | US | disclosed |
| EP-0626969-A4 | CoA-IT AND PAF INHIBITORS. | SMITHKLINE BEECHAM CORP (US) | 1995-04-19 | — | — | EP | disclosed |
| EP-0626969-A1 | CoA-IT AND PAF INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-12-07 | — | — | EP | disclosed |
| WO-1993016674-A1 | CoA-IT AND PAF INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-09-02 | — | — | WO | disclosed |
| EP-0550502-A1 | SUBSTITUTED IMIDAZOLES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1993-07-14 | — | — | EP | disclosed |
| US-5116934-A | Polyethers | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION (US) | 1992-05-26 | — | — | US | disclosed |
| WO-1992004330-A1 | SUBSTITUTED IMIDAZOLES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1992-03-19 | — | — | WO | disclosed |
| US-5066811-A | Di(hydroxyphenyl)imidazole monomers used to make polyethers | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION (US) | 1991-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170130124-A1 | PENTAARYLBIIMIDAZOLE COMPOUND AND PRODUCTION METHOD FOR SAID COMPOUND | PPOX, CDK4, PAICS | MAPK13 250/4885MAPK12 745/4885MAPK11 548/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.