Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.70 |
| ▸ | MAPK13 | O15264 | 14/20 | 0.70 |
| ▸ | MAPK12 | P53778 | 14/20 | 0.70 |
| ▸ | MAPK11 | Q15759 | 14/20 | 0.70 |
| ▸ | RAF1 | P04049 | 4/20 | 0.70 |
| ▸ | BRAF | P15056 | 2/20 | 0.59 |
| ▸ | GCGR | P47871 | 10/20 | 0.59 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.59 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.57 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.57 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.57 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.57 |
| ▸ | FRK | P42685 | 2/20 | 0.57 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.57 |
| ▸ | GSK3B | P49841 | 2/20 | 0.57 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.57 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.57 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.57 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.55 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15075635 | 0.87 | MAPK14 (0.78) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL15075633 | 0.79 | BRAF (0.91) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL9736817 | 0.79 | MAPK13 (0.71) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL6467812 | 0.76 | MAPK14 (0.76) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL2649049 | 0.75 | MAPK14 (0.78) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL2817926 | 0.74 | CYP11B1 (0.49) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL4552316 | 0.74 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL9195042 | 0.74 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL2837756 | 0.74 | HPGDS (0.63) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL2649482 | 0.73 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130165472-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165472-A1 | HETEROARYLS AND USES THEREOF | PIK3R4, VPS4B, PIK3C2A | MAPK14 1023/4885MAPK13 1623/4885MAPK12 2139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.