Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 8/20 | 0.58 |
| ▸ | CYP11B2 | P19099 | 8/20 | 0.58 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17955436 | 0.81 | CYP11B1 (0.57) | CYP11B1CYP11B2ELOVL1CYP19A1GRIN1 | |
| SCHEMBL15076166 | 0.76 | MAPT (0.45) | CYP11B1CYP11B2L3MBTL1 | |
| SCHEMBL13659181 | 0.75 | CYP11B1 (0.53) | CYP11B1CYP11B2ELOVL1CYP19A1 | |
| SCHEMBL15986618 | 0.74 | MAPT (0.44) | ALDH1A1TDP1L3MBTL1 | |
| SCHEMBL1142182 | 0.72 | CYP11B1 (0.50) | CYP11B1CYP11B2ELOVL1CYP19A1ALDH1A1 | |
| SCHEMBL27090052 | 0.72 | L3MBTL1 (0.51) | ALDH1A1TDP1L3MBTL1HTR1ADRD2 | |
| SCHEMBL26023956 | 0.71 | L3MBTL1 (0.46) | ALDH1A1TDP1L3MBTL1 | |
| SCHEMBL30952778 | 0.71 | CYP11B1 (0.61) | CYP11B1CYP11B2ELOVL1CYP19A1GRIN1 | |
| SCHEMBL14117472 | 0.71 | ALDH1A1 (0.55) | CYP19A1ALDH1A1TDP1L3MBTL1 | |
| SCHEMBL29960305 | 0.71 | CYP11B1 (0.56) | CYP11B1CYP11B2ELOVL1CYP19A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013091773-A1 | TETRAAZA-CYCLOPENTA[A]INDENYL AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS | MERCK PATENT GMBH (DE) | 2013-06-27 | — | — | WO | disclosed |