Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.41 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.40 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15062003 | 0.83 | SYK (0.46) | MAPTKDM4ESMN1; SMN2SYKRAB9A | |
| SCHEMBL17955464 | 0.80 | ALDH1A1 (0.48) | MAPTKDM4ESMN1; SMN2SYKRAB9A | |
| SCHEMBL2558141 | 0.77 | SYK (0.44) | MAPTKDM4ESMN1; SMN2SYKRAB9A | |
| SCHEMBL15076151 | 0.76 | CYP11B1 (0.58) | CYP11B1CYP11B2L3MBTL1 | |
| SCHEMBL15986618 | 0.76 | MAPT (0.44) | MAPTKDM4ENPSR1L3MBTL1P2RY1 | |
| SCHEMBL26023956 | 0.73 | L3MBTL1 (0.46) | MAPTKDM4ESMN1; SMN2NPSR1L3MBTL1 | |
| SCHEMBL12301168 | 0.73 | CA12 (0.47) | MAPTSMN1; SMN2SYKKMT2AHTT | |
| SCHEMBL15713604 | 0.72 | L3MBTL1 (0.52) | MAPTKDM4ENPSR1L3MBTL1HTT | |
| SCHEMBL15062006 | 0.72 | IDO1 (0.46) | MAPTNPSR1L3MBTL1HTT | |
| SCHEMBL17689116 | 0.71 | L3MBTL1 (0.42) | MAPTKDM4ENPSR1L3MBTL1P2RY1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013091773-A1 | TETRAAZA-CYCLOPENTA[A]INDENYL AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS | MERCK PATENT GMBH (DE) | 2013-06-27 | — | — | WO | disclosed |