Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.41 |
| ▸ | KIF11 | P52732 | 5/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.39 |
| ▸ | FLT3 | P36888 | 2/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12258101 | 0.83 | KIF11 (0.44) | GSK3BKIF11HTR1DFGFR1FLT3 | |
| SCHEMBL15078644 | 0.80 | ITK (0.44) | GSK3BKIF11ABL1ITK | |
| SCHEMBL12365607 | 0.76 | GSK3B (0.49) | GSK3BKIF11FGFR1FLT3CLK4 | |
| SCHEMBL10061629 | 0.74 | YTHDC1 (0.47) | FLT3PDPK1CDK2TRPA1 | |
| SCHEMBL10152397 | 0.74 | KIF11 (0.47) | GSK3BKIF11FGFR1FLT3CLK4 | |
| SCHEMBL12962020 | 0.74 | KIF11 (0.47) | GSK3BKIF11FGFR1FLT3CLK4 | |
| SCHEMBL84515 | 0.74 | PDPK1 (0.55) | GSK3BKIF11FGFR1FLT3CLK4 | |
| SCHEMBL23478517 | 0.72 | KIF11 (0.46) | GSK3BKIF11HTR1AHTR1DHTR1B | |
| SCHEMBL14738709 | 0.72 | KIF11 (0.46) | GSK3BKIF11FGFR1FLT3CLK4 | |
| SCHEMBL13552135 | 0.72 | KIF11 (0.42) | GSK3BKIF11FGFR1FLT3CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130165440-A1 | JAK1 Inhibitors | EXELIXIS, INC. (US) | 2013-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165440-A1 | JAK1 Inhibitors | JAK1, JAK2, JAK3 | GSK3B 168/4885KIF11 2675/4885HTR1A 315/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.