Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 9/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | MAP2K4 | P45985 | 3/20 | 0.37 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.36 |
| ▸ | MAPKAPK3 | Q16644 | 2/20 | 0.36 |
| ▸ | MAPK6 | Q16659 | 2/20 | 0.36 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL130781 | 0.81 | ITK (0.47) | ITKHSD17B10SMN1; SMN2MAP2K4MAP2K7 | |
| SCHEMBL15077178 | 0.80 | GSK3B (0.41) | ITKKIF11GSK3BABL1 | |
| SCHEMBL10061629 | 0.77 | YTHDC1 (0.47) | KDM4EALDH1A1HSD17B10RAB9ASMN1; SMN2 | |
| SCHEMBL14564411 | 0.74 | MAPT (0.49) | ITKKDM4EALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL14564361 | 0.74 | SMN1; SMN2 (0.55) | ITKKDM4EALDH1A1SMN1; SMN2MAP2K4 | |
| SCHEMBL14942621 | 0.74 | ITK (0.47) | ITKMAP2K4MAP2K7MAPK1MAPKAPK2 | |
| SCHEMBL19853511 | 0.73 | HSP90AA1 (0.42) | ITKLMNAMAP2K4HSP90AA1HSP90AB1 | |
| SCHEMBL31552439 | 0.72 | ITK (0.53) | ITKMAP2K4MAP2K7MAPK1MAPKAPK2 | |
| SCHEMBL12247 | 0.72 | ITK (0.53) | ITKMAP2K4MAP2K7MAPK1MAPKAPK2 | |
| SCHEMBL14451980 | 0.72 | FADS1 (0.46) | LMNAHTTGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130165440-A1 | JAK1 Inhibitors | EXELIXIS, INC. (US) | 2013-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165440-A1 | JAK1 Inhibitors | JAK1, JAK2, JAK3 | ITK 2317/4885KDM4E 1141/4885ALDH1A1 1886/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.