Sugi Predict

Sugi Predict / Compounds / SCHEMBL15079079

SCHEMBL15079079

SCHEMBL15079079

COC(=O)[C@H]1C[C@@H](N)CN1C

nearest known ligand 0.64

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ MMP2 P08253 6/20 0.64
▸ ANPEP P15144 4/20 0.64
▸ BRD4 O60885 1/20 0.37
▸ MMP1 P03956 1/20 0.36
▸ MMP3 P08254 1/20 0.36
▸ MMP7 P09237 1/20 0.36
▸ MMP13 P45452 1/20 0.36
▸ ALDH1A1 P00352 1/20 0.36
▸ GABRR1 P24046 1/20 0.35
▸ CYP3A4 P08684 2/20 0.35
▸ MAPT P10636 2/20 0.35
▸ PEPD P12955 2/20 0.35
▸ XPNPEP1 Q9NQW7 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8049482 1.00 MMP2 (0.64) MMP2ANPEPBRD4MMP1MMP3
SCHEMBL17679758 1.00 MMP2 (0.64) MMP2ANPEPBRD4MMP1MMP3
SCHEMBL14367104 1.00 MMP2 (0.64) MMP2ANPEPBRD4MMP1MMP3
SCHEMBL15079077 1.00 MMP2 (0.64) MMP2ANPEPBRD4MMP1MMP3
Hydrochloric Acid SCHEMBL29414150 0.98 MMP2 (0.62) MMP2ANPEPBRD4MMP1MMP3
Hydrochloric Acid SCHEMBL30337475 0.98 MMP2 (0.62) MMP2ANPEPBRD4MMP1MMP3
Hydrochloric Acid SCHEMBL29129130 0.98 MMP2 (0.62) MMP2ANPEPBRD4MMP1MMP3
SCHEMBL13865290 0.83 ANPEP (0.49) MMP2ANPEPBRD4ALDH1A1GABRR1
SCHEMBL18536557 0.81 ANPEP (0.51) MMP2ANPEPALDH1A1CYP3A4MAPT
SCHEMBL14288714 0.80 MMP2 (0.42) MMP2ANPEPALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2794611-B1 PYRAZOLO[1,5-A]PYRIMIDINES AS ANTIVIRAL AGENTS GILEAD SCIENCES INC (US) 2017-10-11 — — EP disclosed
US-20160235748-A1 PYRAZOLO[1,5-A]PYRIMIDINES AS ANTIVIRAL AGENTS GILEAD SCIENCES, INC. 2016-08-18 — — US disclosed
US-9278975-B2 Pyrazolo[1,5-A]pyrimidines as antiviral agents GILEAD SCIENCES, INC. (US) 2016-03-08 — — US disclosed
US-20150166546-A1 PYRAZOLO[1,5-A]PYRIMIDINES AS ANTIVIRAL AGENTS GILEAD SCIENCES, INC. 2015-06-18 — — US disclosed
US-8946238-B2 Pyrazolo[1,5-A]pyrimidines as antiviral agents GILEAD SCIENCES, INC. (US) 2015-02-03 — — US disclosed
US-20130164280-A1 PYRAZOLO[1,5-A]PYRIMIDINES AS ANTIVIRAL AGENTS GILEAD SCIENCES, INC. (US) 2013-06-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130164280-A1 PYRAZOLO[1,5-A]PYRIMIDINES AS ANTIVIRAL AGENTS TYMP, ZC3HAV1, TYMS MMP2 4523/4885ANPEP 1097/4885BRD4 1551/4885
US-20150166546-A1 PYRAZOLO[1,5-A]PYRIMIDINES AS ANTIVIRAL AGENTS TYMP, ZC3HAV1, TYMS MMP2 4523/4885ANPEP 1097/4885BRD4 1551/4885
US-20160235748-A1 PYRAZOLO[1,5-A]PYRIMIDINES AS ANTIVIRAL AGENTS TYMP, ZC3HAV1, TYMS MMP2 4523/4885ANPEP 1097/4885BRD4 1551/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.