Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 4/20 | 0.44 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.43 |
| ▸ | CKS1B | P61024 | 1/20 | 0.42 |
| ▸ | SKP1 | P63208 | 1/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.42 |
| ▸ | CCRL2 | O00421 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 3/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15424455 | 0.79 | KDM1A (0.47) | KDM1AMAOBKMT2AL3MBTL1DRD2 | |
| SCHEMBL612810 | 0.76 | KDM1A (0.53) | KDM1AMAOBKMT2AL3MBTL1DRD2 | |
| SCHEMBL3865823 | 0.75 | KDM1A (0.52) | KDM1AMAOBKMT2AL3MBTL1DRD2 | |
| SCHEMBL13999223 | 0.75 | KDM1A (0.58) | KDM1AMAOBKMT2AL3MBTL1DRD2 | |
| SCHEMBL23335033 | 0.74 | CTSK (0.49) | KDM1AMAOBKMT2AL3MBTL1DRD2 | |
| SCHEMBL12794285 | 0.73 | CTSK (0.52) | KDM1AMAOBKMT2AL3MBTL1DRD2 | |
| SCHEMBL12794288 | 0.73 | CTSK (0.52) | KDM1AMAOBKMT2AL3MBTL1DRD2 | |
| SCHEMBL23689558 | 0.72 | KMT2A (0.61) | KDM1AMAOBKMT2AL3MBTL1DRD2 | |
| SCHEMBL30504899 | 0.72 | CTSK (0.47) | KDM1AMAOBKMT2AL3MBTL1DRD2 | |
| SCHEMBL2647959 | 0.71 | KDM1A (0.62) | KDM1AMAOBKMT2AL3MBTL1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130165424-A9 | DISPIROPYRROLIDINE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165424-A9 | DISPIROPYRROLIDINE DERIVATIVES | MDM2, TP53, TP53BP1 | KDM1A 1256/4885MAOB 4288/4885KMT2A 1997/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.