Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 6/20 | 0.50 |
| ▸ | DRD3 | P35462 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.50 |
| ▸ | CKS1B | P61024 | 1/20 | 0.50 |
| ▸ | SKP1 | P63208 | 1/20 | 0.50 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.49 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17830852 | 0.87 | CKS1B (0.61) | KDM1AMAOBDRD2DRD3KMT2A | |
| SCHEMBL30817389 | 0.85 | MEN1 (0.60) | DRD2KMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL12794288 | 0.84 | CTSK (0.52) | KDM1AMAOBDRD2KMT2AL3MBTL1 | |
| SCHEMBL12794285 | 0.84 | CTSK (0.52) | KDM1AMAOBDRD2KMT2AL3MBTL1 | |
| SCHEMBL13999223 | 0.83 | KDM1A (0.58) | KDM1AMAOBDRD2KMT2AL3MBTL1 | |
| SCHEMBL3884233 | 0.83 | DRD2 (0.55) | DRD2GPR119CKS1BSKP1SKP2 | |
| SCHEMBL23689558 | 0.83 | KMT2A (0.61) | KDM1AMAOBDRD2DRD3KMT2A | |
| SCHEMBL3865622 | 0.82 | DRD2 (0.67) | DRD2 | |
| SCHEMBL8470810 | 0.81 | DRD2 (0.53) | KDM1AMAOBDRD2DRD3KMT2A | |
| SCHEMBL8470808 | 0.81 | DRD2 (0.53) | KDM1AMAOBDRD2DRD3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7517885-B2 | Substituted [4-(4-phenyl-piperazin-1-yl)-cyclohexyl]-urea compounds | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-04-14 | — | — | US | disclosed |
| US-7459557-B2 | Substituted isoindole-1,3-diones | JANSSEN PHARMACEUTICA N.V. (BG) | 2008-12-02 | — | — | US | disclosed |
| US-7459557-B2 | Substituted isoindole-1,3-diones | JANSSEN PHARMACEUTICA N.V. (BG) | 2008-12-02 | — | — | US | disclosed |
| US-20070123542-A1 | Substituted [4-(4-phenyl-piperazin-1-yl)-cyclohexyl]-urea compounds | CHIU GEORGE | 2007-05-31 | — | — | US | disclosed |
| US-20070093500-A1 | Substituted isoindole-1,3-diones | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-04-26 | — | — | US | disclosed |
| US-20070093500-A1 | Substituted isoindole-1,3-diones | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-04-26 | — | — | US | disclosed |
| WO-2007005214-A1 | SUBSTITUTED {4(4-PHENYL-PIPERAZIN-1YL)-CYCLOHEXYL}-UREA COMPOUNDS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-01-11 | — | — | WO | disclosed |
| WO-2007001818-A2 | SUBSTITUTED ISOINDOLE-1,3-DIONES | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-01-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070123542-A1 | Substituted [4-(4-phenyl-piperazin-1-yl)-cyclohexyl]-urea compounds | ADRA1D, ADRA1A, ADRB1 | KDM1A 1175/4885MAOB 999/4885DRD2 662/4885 |
| US-20070093500-A1 | Substituted isoindole-1,3-diones | ADRA1D, ADRA1A, ADRB1 | KDM1A 1981/4885MAOB 411/4885DRD2 94/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.