Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7969941 | 1.00 | SMN1; SMN2 (0.43) | SMN1; SMN2MAPTTP53CHRNB2CHRNA4 | |
| SCHEMBL6955087 | 0.85 | SLC6A4 (0.48) | NPC1RAB9ADRD2MEN1CYP3A4 | |
| SCHEMBL3364553 | 0.85 | SLC6A4 (0.48) | NPC1RAB9ADRD2MEN1CYP3A4 | |
| SCHEMBL15080463 | 0.79 | SLC6A4 (0.49) | TP53DRD2 | |
| SCHEMBL8364563 | 0.76 | SLC6A4 (0.58) | NPC1RAB9ADRD2MEN1CYP3A4 | |
| SCHEMBL15080461 | 0.74 | HTR2A (0.36) | — | |
| SCHEMBL6946241 | 0.70 | SLC6A4 (0.57) | — | |
| SCHEMBL2336203 | 0.69 | POLB (0.68) | SMN1; SMN2MAPTPKMNPC1RAB9A | |
| SCHEMBL29990241 | 0.69 | POLB (0.68) | SMN1; SMN2MAPTPKMNPC1RAB9A | |
| SCHEMBL7955308 | 0.68 | ALDH1A1 (0.49) | MAPTTP53RAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8475804-B2 | Compositions and methods for treatment of filovirus-mediated diseases | U.S. ARMY MEDICAL RESEARCH AND MATERIAL COMMAND (US) | 2013-07-02 | — | — | US | disclosed |