Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.65 |
| ▸ | DRD2 | P14416 | 3/20 | 0.65 |
| ▸ | ABCB1 | P08183 | 8/20 | 0.56 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.52 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.52 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.52 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.50 |
| ▸ | LIPE | Q05469 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | MGLL | Q99685 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15701376 | 0.85 | HTR1A (0.57) | HTR1ADRD2ABCB1PTGER1PTGER4 | |
| SCHEMBL15701381 | 0.85 | HTR1A (0.57) | HTR1ADRD2ABCB1PTGER1PTGER4 | |
| SCHEMBL10869458 | 0.81 | HTR1A (0.56) | HTR1ADRD2ABCB1PTGER1PTGER4 | |
| SCHEMBL10758587 | 0.81 | HTR1A (0.56) | HTR1ADRD2ABCB1PTGER1PTGER4 | |
| SCHEMBL7535470 | 0.80 | TAAR1 (0.56) | ABCB1HPGD | |
| SCHEMBL3268053 | 0.80 | HTR1A (0.73) | HTR1ADRD2ABCB1PTGER1PTGER4 | |
| SCHEMBL10784832 | 0.80 | HTR1A (0.73) | HTR1ADRD2ABCB1PTGER1PTGER4 | |
| SCHEMBL17197391 | 0.79 | HTR1A (0.79) | HTR1ADRD2ABCB1PTGER1PTGER4 | |
| SCHEMBL4183309 | 0.79 | HTR1A (1.00) | HTR1ADRD2ABCB1PTGER1PTGER4 | |
| SCHEMBL2942774 | 0.78 | TSHR (0.53) | HTR1ATDP1MAPK1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476287-B2 | 3-hydroxy-5-arylisothiazole derivative | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2013-07-02 | — | — | US | disclosed |