Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 1.00 |
| ▸ | DRD2 | P14416 | 5/20 | 1.00 |
| ▸ | ABCB1 | P08183 | 13/20 | 0.81 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.67 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.60 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.60 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.60 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9057460 | 0.89 | HTR1A (0.79) | HTR1ADRD2ABCB1ABCG2PTGER1 | |
| SCHEMBL17197391 | 0.88 | HTR1A (0.79) | HTR1ADRD2ABCB1ABCG2PTGER1 | |
| SCHEMBL2989204 | 0.88 | HTR1A (0.77) | HTR1ADRD2ABCB1ABCG2PTGER1 | |
| SCHEMBL15726355 | 0.86 | PTGER1 (0.84) | HTR1ADRD2ABCB1ABCG2PTGER1 | |
| SCHEMBL8406722 | 0.86 | PTGER1 (0.84) | HTR1ADRD2ABCB1ABCG2PTGER1 | |
| SCHEMBL13009602 | 0.85 | HTR1A (0.74) | HTR1ADRD2ABCB1ABCG2PTGER1 | |
| SCHEMBL23881745 | 0.85 | HTR1A (0.73) | HTR1ADRD2ABCB1ABCG2PTGER1 | |
| SCHEMBL3268053 | 0.85 | HTR1A (0.73) | HTR1ADRD2ABCB1ABCG2PTGER1 | |
| SCHEMBL10784832 | 0.85 | HTR1A (0.73) | HTR1ADRD2ABCB1ABCG2PTGER1 | |
| SCHEMBL7616541 | 0.85 | HTR1A (0.73) | HTR1ADRD2ABCB1ABCG2PTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090093493-A1 | 1-PHENYLALCOXY-2-BETA-PHENYLETHYL DERIVATIVES AS P-GLYCOPROTEIN (P-GP) INHIBITORS USEFUL IN DRUG RESISTANCE EVENTS | UNIVERSITA DI PISA, 40% (IT) | 2009-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090093493-A1 | 1-PHENYLALCOXY-2-BETA-PHENYLETHYL DERIVATIVES AS P-GLYCOPROTEIN (P-GP) INHIBITORS USEFUL IN DRUG RESISTANCE EVENTS | ABCB1, ABCC1, ABCC2 | HTR1A 2320/4885DRD2 1431/4885ABCB1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.