Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | PPARD | Q03181 | 11/20 | 0.57 |
| ▸ | PPARA | Q07869 | 9/20 | 0.57 |
| ▸ | PPARG | P37231 | 7/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | FFAR1 | O14842 | 7/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.52 |
| ▸ | CRHBP | P24387 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3374725 | 0.88 | MAPT (0.60) | NPC1ALDH1A1GAAPPARDPPARA | |
| SCHEMBL11926060 | 0.86 | NPC1 (0.56) | NPC1ALDH1A1GAAPPARDPPARA | |
| SCHEMBL3371906 | 0.86 | MAPT (0.55) | NPC1ALDH1A1GAAPPARDPPARA | |
| SCHEMBL5016720 | 0.86 | MAPT (0.57) | NPC1ALDH1A1GAAPPARDPPARA | |
| SCHEMBL4472919 | 0.85 | ALDH1A1 (0.45) | NPC1ALDH1A1GAAPPARDPPARA | |
| SCHEMBL5015456 | 0.85 | NPC1 (0.54) | NPC1ALDH1A1GAAPPARDPPARA | |
| SCHEMBL12151262 | 0.85 | NPC1 (0.54) | NPC1ALDH1A1GAAPPARDPPARA | |
| SCHEMBL1553917 | 0.85 | NPC1 (0.54) | NPC1ALDH1A1GAAPPARDPPARA | |
| SCHEMBL3822273 | 0.85 | NPC1 (0.58) | NPC1ALDH1A1GAAPPARDPPARA | |
| SCHEMBL27717557 | 0.85 | NPC1 (0.54) | NPC1ALDH1A1GAAPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 160 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240166613-A1 | PROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR) COMPOUNDS AND METHODS OF USING THE SAME | THE UNIVERSITY OF TOLEDO (US) | 2024-05-23 | — | — | US | disclosed |
| US-11897852-B2 | Proxisome proliferator activated receptor (PPAR) compounds and methods of using the same | THE UNIVERSITY OF TOLEDO (US) | 2024-02-13 | — | — | US | disclosed |
| US-20210163431-A1 | PROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR) COMPOUNDS AND METHODS OF USING THE SAME | THE UNIVERSITY OF TOLEDO (US) | 2021-06-03 | — | — | US | disclosed |
| US-10941125-B2 | Proxisome proliferator activated receptor (PPAR) compounds and methods of using the same | THE UNIVERSITY OF TOLEDO (US) | 2021-03-09 | — | — | US | disclosed |
| US-20190330166-A1 | Proxisome Proliferator Activated Receptor (PPAR) Compounds and Methods of Using the Same | THE UNIVERSITY OF TOLEDO (US) | 2019-10-31 | — | — | US | disclosed |
| US-10351541-B2 | Proxisome proliferator activated receptor (PPAR) compounds and methods of using the same | THE UNIVERSITY OF TOLEDO (US) | 2019-07-16 | — | — | US | disclosed |
| US-20170283385-A1 | Proxisome Proliferator Activated Receptor (PPAR) Compounds and Methods of Using the Same | THE UNIVERSITY OF TOLEDO (US) | 2017-10-05 | — | — | US | disclosed |
| US-9695137-B2 | Analogs of peroxisome proliferator activated receptor (PPAR) agonists, and methods of using the same | THE UNIVERSITY OF TOLEDO (US) | 2017-07-04 | — | — | US | disclosed |
| US-20160016920-A1 | Analogs of Peroxisome Proliferator Activated Receptor (PPAR) Agonists, and Methods of Using the Same | THE UNIVERSITY OF TOLEDO (US) | 2016-01-21 | — | — | US | disclosed |
| WO-2014152809-A2 | ANALOGS OF PPARO AND 20-OH-PGE2, AND METHODS OF USING THE SAME | THE UNIVERSITY OF TOLEDO (US) | 2014-09-25 | — | — | WO | disclosed |
| US-20040110807-A1 | Thiazole derivatives | HOFFMANN-LA ROCHE INC. | 2004-06-10 | — | — | US | disclosed |
| US-20040102493-A1 | Thia-and oxazoles and their use as ppars activators | SMITHKLINE BEECHAM CORPORATION | 2004-05-27 | — | — | US | disclosed |
| WO-2004020420-A1 | NOVEL 2-ARYLTHIAZOLE COMPOUNDS AS PPARALPHA AND PPARGAMA AGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2004-03-11 | — | — | WO | disclosed |
| WO-2003106442-A1 | PROCESS FOR PREPARING THIAZOLE DERIVATIVE AND THE INTERMEDIATE COMPOUNDS FOR PREPARING THE SAME | KANG HEONJOONG (KR) | 2003-12-24 | — | — | WO | disclosed |
| US-20030207924-A1 | Compounds that modulate PPAR activity and methods of preparation | CHENG XUE-MIN (US) | 2003-11-06 | — | — | US | disclosed |
| EP-1343772-A1 | THIA- AND OXAZOLES AND THEIR USE AS PPARS ACTIVATORS | GLAXO GROUP LIMITED (GB) | 2003-09-17 | — | — | EP | disclosed |
| WO-2003074050-A1 | THIAZOLE AND OXAZOLE DERIVATIVES WHICH MODULATE PPAR ACTIVITY | WARNER-LAMBERT COMPANY LLC (US) | 2003-09-12 | — | — | WO | disclosed |
| WO-2003072102-A1 | PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2003-09-04 | — | — | WO | disclosed |
| WO-2003072100-A1 | PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2003-09-04 | — | — | WO | disclosed |
| WO-2002050048-A1 | THIA- AND OXAZOLES AND THEIR USE AS PPARS ACTIVATORS | GLAXO GROUP LIMITED (GB) | 2002-06-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040102493-A1 | Thia-and oxazoles and their use as ppars activators | PPARA, PPARG, NCOA1 | NPC1 779/4885ALDH1A1 2302/4885GAA 1390/4885 |
| US-20240166613-A1 | PROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR) COMPOUNDS AND METHODS OF USING THE SAME | PPARG, PPARA, PPARD | NPC1 1480/4885ALDH1A1 1053/4885GAA 1788/4885 |
| US-20190330166-A1 | Proxisome Proliferator Activated Receptor (PPAR) Compounds and Methods of Using the Same | PPARG, PPARA, PPARD | NPC1 1459/4885ALDH1A1 1102/4885GAA 1728/4885 |
| US-10941125-B2 | Proxisome proliferator activated receptor (PPAR) compounds and methods of using the same | PPARG, PPARA, PPARD | NPC1 1459/4885ALDH1A1 1102/4885GAA 1728/4885 |
| US-10351541-B2 | Proxisome proliferator activated receptor (PPAR) compounds and methods of using the same | PPARG, PPARA, PPARD | NPC1 1459/4885ALDH1A1 1102/4885GAA 1728/4885 |
| US-20160016920-A1 | Analogs of Peroxisome Proliferator Activated Receptor (PPAR) Agonists, and Methods of Using the Same | PPARG, PPARA, PPARD | NPC1 3749/4885ALDH1A1 651/4885GAA 3281/4885 |
| US-11897852-B2 | Proxisome proliferator activated receptor (PPAR) compounds and methods of using the same | PPARG, PPARA, PPARD | NPC1 1459/4885ALDH1A1 1102/4885GAA 1728/4885 |
| US-20040110807-A1 | Thiazole derivatives | SLC5A1, GPR119, INSR | NPC1 300/4885ALDH1A1 274/4885GAA 1642/4885 |
| US-20210163431-A1 | PROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR) COMPOUNDS AND METHODS OF USING THE SAME | PPARG, PPARA, PPARD | NPC1 1459/4885ALDH1A1 1102/4885GAA 1728/4885 |
| US-20030207924-A1 | Compounds that modulate PPAR activity and methods of preparation | PPARA, PPARD, PPARG | NPC1 147/4885ALDH1A1 886/4885GAA 858/4885 |
| US-20170283385-A1 | Proxisome Proliferator Activated Receptor (PPAR) Compounds and Methods of Using the Same | PPARG, PPARA, PPARD | NPC1 1459/4885ALDH1A1 1102/4885GAA 1728/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.