SCHEMBL1508459

SCHEMBL1508459

C=CC(=O)OC(C)Oc1c(Br)cc(Br)cc1Br

nearest known ligand 0.38

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 1/20 0.38
TSHR P16473 1/20 0.36
ALOX12 P18054 2/20 0.34
LMNA P02545 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
ALOX15 P16050 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.30
MAOA P21397 1/20 0.30
MAOB P27338 1/20 0.30
THRA P10827 1/20 0.30
THRB P10828 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14343253 0.87 THRB (0.36) HSD17B10TSHRALOX15THRATHRB
SCHEMBL6993149 0.85 ALDH1A1 (0.38) HSD17B10TSHRALOX12ALOX15
SCHEMBL14348264 0.85
SCHEMBL14913149 0.83 THRB (0.43) THRATHRB
SCHEMBL7560284 0.81 HSD17B10 (0.35) HSD17B10
SCHEMBL7529262 0.81 SMN1; SMN2 (0.45) TSHRALOX12LMNAALOX15L3MBTL1
SCHEMBL10605592 0.81 HSD17B10 (0.36) HSD17B10TSHRALOX12LMNANPSR1
SCHEMBL10611030 0.80 TSHR (0.36) TSHR
SCHEMBL11022926 0.79 HSD17B10 (0.34) HSD17B10TSHRALOX12LMNANPSR1
SCHEMBL11056615 0.79 HSD17B10 (0.34) HSD17B10ALOX12LMNANPSR1ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0162550-B1 HALOGEN-CONTAINING LENS MATERIAL KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1989-12-13 EP claimed
US-4578445-A Halogen-containing lens material KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1986-03-25 US claimed
JP-61152711-A None JP disclosed
JP-63215706-A None JP disclosed
CN-111372959-B Photopolymerizable compositions, articles, and methods comprising a urethane component and a monofunctional reactive diluent 3M创新有限公司 2022-09-02 CN disclosed
CN-114585604-A Dicarboxylic acid compound, inorganic particle treated with dicarboxylic acid compound, and composition thereof 3M创新有限公司 2022-06-03 CN disclosed
CN-113840886-A Composition comprising styrene-isoprene block copolymer and ethylenically unsaturated monomer 3M创新有限公司 2021-12-24 CN disclosed
CN-113286560-A Orthodontic articles and methods of making and post-treating the same 3M创新有限公司 2021-08-20 CN disclosed
CN-112424245-A Composition comprising styrene-isobutylene block copolymer and ethylenically unsaturated monomer 3M创新有限公司 2021-02-26 CN disclosed
CN-112367959-A Orthodontic articles comprising cured free-radically polymerizable compositions having improved strength in aqueous environments 3M创新有限公司 2021-02-12 CN disclosed
CN-111868125-A Photopolymerizable compositions, articles, and methods comprising polypropylene oxide components 3M创新有限公司 2020-10-30 CN disclosed
JP-S63215706-A RESIN LENS MATERIAL HAVING HIGH REFRACTIVE INDEX KUREHA CHEM IND CO LTD 1988-09-08 JP disclosed
US-4721377-A COPOLYMER OF DIBROMOSTYRENE, DI-(OR TRI-) (METH-)ACRYLATE AND MONO (METH-)ACRYLATE TORAY INDUSTRIES, INC. (JP) 1988-01-26 US disclosed
US-4704006-A HIGH REFRACTIVE INDEX, DYEABILITY, SOLVENT RESISTANCE KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1987-11-03 US disclosed
EP-0142921-B1 HALOGEN-CONTAINING RESIN LENS MATERIAL KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1987-08-26 EP disclosed
JP-S61152711-A PRODUCTION OF CROSSLINKED COPOLYMER HAVING HIGH REFRACTIVE INDEX KUREHA CHEM IND CO LTD 1986-07-11 JP disclosed
EP-0176874-A2 A highly-refractive plastic lens TORAY INDUSTRIES, INC. (JP) 1986-04-09 EP disclosed
US-4578445-A Halogen-containing lens material KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1986-03-25 US disclosed
EP-0162550-A2 Halogen-containing lens material KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1985-11-27 EP disclosed
EP-0142921-A1 Halogen-containing resin lens material KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1985-05-29 EP disclosed