Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA5A | P35218 | 2/20 | 0.40 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NT5E | P21589 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SLC6A6 | P31641 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL1508822 | 1.00 | CA5A (0.40) | CA5ACA5BTP53CA1CA2 | |
| SCHEMBL11148376 | 0.88 | TP53 (0.35) | CA5ACA5BTP53CA1CA2 | |
| SCHEMBL11144259 | 0.85 | TP53 (0.38) | CA5ACA5BTP53CA1CA2 | |
| Sulfuric Acid SCHEMBL5429506 | 0.83 | TP53 (0.41) | CA5ACA5BTP53 | |
| Sulfuric Acid SCHEMBL29043936 | 0.83 | TP53 (0.41) | CA5ACA5BTP53 | |
| Sulfuric Acid SCHEMBL5424303 | 0.83 | TP53 (0.41) | CA5ACA5BTP53 | |
| Sulfuric Acid SCHEMBL29043937 | 0.83 | TP53 (0.41) | CA5ACA5BTP53 | |
| SCHEMBL2354479 | 0.82 | LMNA (0.36) | TSHRLMNA | |
| SCHEMBL74076 | 0.82 | — | — | |
| SCHEMBL3875790 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2288348-A1 | NANOPARTICLES FUNCTIONALIZED WITH SULFATED AMINO ALCOHOLS FOR THE INHIBITION OF SELECTIN-MEDIATED CELL ADHESION | Freie Universität Berlin (DE) | 2011-03-02 | — | — | EP | disclosed |
| WO-2009141142-A1 | NANOPARTICLES FUNCTIONALIZED WITH SULFATED AMINO ALCOHOLS FOR THE INHIBITION OF SELECTIN-MEDIATED CELL ADHESION | FREIE UNIVERSITÄT BERLIN (DE) | 2009-11-26 | — | — | WO | disclosed |
| EP-2123269-A1 | Nanoparticles functionalized with sulfated amino alcohols for the inhibition of selectin-mediated cell adhesion | Freie Universität Berlin (DE) | 2009-11-25 | — | — | EP | disclosed |
| EP-1075835-A1 | Use of aminodiol derivatives in skin cosmeics | SHISEIDO COMPANY LIMITED (JP) | 2001-02-14 | — | — | EP | disclosed |