SCHEMBL15085554

SCHEMBL15085554

CNC(=O)c1cc(C#N)cc(C)c1NC(=O)C1CC(c2ncccc2S(=O)(=O)O)=NN1c1ncccc1Cl

nearest known ligand 0.40

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
MALT1 Q9UDY8 6/20 0.35
TP53 P04637 1/20 0.32
MAPT P10636 1/20 0.32
GRM4 Q14833 1/20 0.30
TYK2 P29597 1/20 0.30
KMT2A Q03164 1/20 0.30
MTOR P42345 1/20 0.30
RPTOR Q8N122 1/20 0.30
MLST8 Q9BVC4 1/20 0.30
TRPV1 Q8NER1 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15085604 0.91 MALT1 (0.38) MALT1TP53MAPTGRM4KMT2A
SCHEMBL15085539 0.89 MALT1 (0.35) MALT1GRM4TYK2KMT2AMTOR
SCHEMBL15085579 0.88 GRM5 (0.35) MALT1TP53MAPT
SCHEMBL15085532 0.88 MALT1 (0.32) MALT1TP53MAPT
SCHEMBL15085541 0.88 MALT1 (0.36) MALT1TP53TYK2MTORRPTOR
SCHEMBL15085560 0.87 SMN1; SMN2 (0.32) MALT1TP53MAPTKMT2A
SCHEMBL9290062 0.86 MALT1 (0.40) MALT1TYK2KMT2A
SCHEMBL1148490 0.85 MALT1 (0.40) MALT1GRM4TYK2KMT2ATRPV1
SCHEMBL902832 0.84 MALT1 (0.39) MALT1GRM4TYK2KMT2A
SCHEMBL12437107 0.82 MALT1 (0.38) MALT1TYK2KMT2ATRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8481744-B2 Process for producing anthranilamide compound ISHIHARA SANGYO KAISHA, LTD. (JP) 2013-07-09 US disclosed