SCHEMBL902832

SCHEMBL902832

CNC(=O)c1cc(C#N)cc(C)c1NC(=O)C1CC(Br)=NN1c1ncccc1Cl

nearest known ligand 0.49

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
MALT1 Q9UDY8 9/20 0.39
DHODH Q02127 1/20 0.34
TYK2 P29597 1/20 0.34
KMT2A Q03164 1/20 0.34
PHGDH O43175 1/20 0.33
FASN P49327 1/20 0.33
PPARG P37231 1/20 0.33
RORC P51449 1/20 0.32
TNF P01375 1/20 0.32
IRAK4 Q9NWZ3 1/20 0.32
GRM4 Q14833 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12296401 0.92 MALT1 (0.38) MALT1DHODHTYK2KMT2APHGDH
SCHEMBL9290062 0.92 MALT1 (0.40) MALT1TYK2KMT2ATNFIRAK4
SCHEMBL1148490 0.91 MALT1 (0.40) MALT1TYK2KMT2APHGDHTNF
SCHEMBL1148395 0.90 MALT1 (0.43) MALT1DHODHPHGDHGRM4
SCHEMBL9290241 0.90 MALT1 (0.41) MALT1DHODHPHGDHGRM4
SCHEMBL13242773 0.89 IRAK4 (0.37) MALT1DHODHTYK2KMT2ARORC
SCHEMBL13002825 0.89 MALT1 (0.40) MALT1DHODHPHGDHGRM4
SCHEMBL12438369 0.89 MALT1 (0.40) MALT1DHODHPHGDHGRM4
SCHEMBL12437107 0.88 MALT1 (0.38) MALT1TYK2KMT2A
SCHEMBL13243142 0.87 MALT1 (0.34) MALT1DHODHTYK2KMT2APPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8481744-B2 Process for producing anthranilamide compound ISHIHARA SANGYO KAISHA, LTD. (JP) 2013-07-09 US disclosed
EP-2264021-B1 PROCESS FOR PRODUCING AN ANTHRANILAMIDE COMPOUND ISHIHARA SANGYO KAISHA (JP) 2013-06-26 EP disclosed
WO-2012092827-A1 CHEMICAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2012-07-12 WO disclosed
WO-2012069652-A2 FUNGICIDE MIXTURES SYNGENTA PARTICIPATIONS AG (CH) 2012-05-31 WO disclosed
WO-2012069008-A1 3-SUBSTITUTED SPIROHETEROCYCLIC FURAN AND THIOFURAN DIONE DERIVATIVES USEFUL AS PESTICIDES SYNGENTA PARTICIPATIONS AG (CH) 2012-05-31 WO disclosed
WO-2012041874-A1 FUNGICIDAL COMPOSITIONS SYNGENTA PARTICIPATIONS AG (CH) 2012-04-05 WO disclosed
WO-2012013754-A1 NOVEL MICROBIOCIDAL DIOXIME ETHER DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2012-02-02 WO disclosed
WO-2011104183-A1 NOVEL MICROBICIDES SYNGENTA PARTICIPATIONS AG (CH) 2011-09-01 WO disclosed
WO-2011095461-A1 PYRIDAZINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS FUNGICIDES SYNGENTA PARTICIPATIONS AG (CH) 2011-08-11 WO disclosed
US-20110034696-A1 PROCESS FOR PRODUCING ANTHRANILAMIDE COMPOUND ISHIHARA SANGYO KAISHA, LTD. (JP) 2011-02-10 US disclosed
WO-2010118946-A2 FUNGICIDAL MIXTURES SYNGENTA PARTICIPATIONS AG (CH) 2010-10-21 WO disclosed
EP-2206431-A1 Fungicidal Compositions Sygenta Participations AG. (CH) 2010-07-14 EP disclosed
EP-2204093-A1 Fungicidal Compositions Sygenta Participations AG. (CH) 2010-07-07 EP disclosed
EP-2201839-A1 Fungicidal compositions Syngenta Participations AG (CH) 2010-06-30 EP disclosed
EP-2196089-A1 Fungicidal Compositions Sygenta Participations AG. (CH) 2010-06-16 EP disclosed
EP-2196088-A1 Fungicidal Compositions Syngenta Participations AG (CH) 2010-06-16 EP disclosed
EP-2193715-A1 Fungicidal Compositions Sygenta Participations AG. (CH) 2010-06-09 EP disclosed
EP-2193714-A1 Fungicidal Compositions Sygenta Participations AG. (CH) 2010-06-09 EP disclosed
EP-2193716-A1 Fungicidal Compositions Syngenta Participations AG (CH) 2010-06-09 EP disclosed
EP-2193717-A1 Fungicidal Compositions Sygenta Participations AG. (CH) 2010-06-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110034696-A1 PROCESS FOR PRODUCING ANTHRANILAMIDE COMPOUND SQOR, NOX5, NOX3 MALT1 3967/4885DHODH 149/4885TYK2 1145/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.