SCHEMBL1148490

SCHEMBL1148490

CNC(=O)c1cc(C#N)cc(C)c1NC(=O)C1CC(O)=NN1c1ncccc1Cl

nearest known ligand 0.46

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
MALT1 Q9UDY8 11/20 0.40
TYK2 P29597 1/20 0.34
KMT2A Q03164 1/20 0.34
TNF P01375 1/20 0.33
IRAK4 Q9NWZ3 1/20 0.33
GRM4 Q14833 1/20 0.33
TRPV1 Q8NER1 1/20 0.32
GPR6 P46095 1/20 0.32
PHGDH O43175 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9290062 0.93 MALT1 (0.40) MALT1TYK2KMT2ATNFIRAK4
SCHEMBL902832 0.91 MALT1 (0.39) MALT1TYK2KMT2ATNFIRAK4
SCHEMBL1148344 0.90 MALT1 (0.44) MALT1GRM4TRPV1
SCHEMBL12437107 0.89 MALT1 (0.38) MALT1TYK2KMT2ATRPV1
SCHEMBL15085539 0.85 MALT1 (0.35) MALT1TYK2KMT2AGRM4
SCHEMBL15085554 0.85 MALT1 (0.35) MALT1TYK2KMT2AGRM4TRPV1
SCHEMBL1148234 0.85 MALT1 (0.35) MALT1TYK2KMT2AGPR6
SCHEMBL1148434 0.85 MALT1 (0.35) MALT1TYK2KMT2AGPR6
SCHEMBL1148432 0.84 MALT1 (0.34) MALT1GPR6
SCHEMBL15085541 0.84 MALT1 (0.36) MALT1TYK2TNFIRAK4GPR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8481744-B2 Process for producing anthranilamide compound ISHIHARA SANGYO KAISHA, LTD. (JP) 2013-07-09 US disclosed
EP-2264021-B1 PROCESS FOR PRODUCING AN ANTHRANILAMIDE COMPOUND ISHIHARA SANGYO KAISHA (JP) 2013-06-26 EP disclosed
US-20110034696-A1 PROCESS FOR PRODUCING ANTHRANILAMIDE COMPOUND ISHIHARA SANGYO KAISHA, LTD. (JP) 2011-02-10 US disclosed
EP-2264021-A1 PROCESS FOR PRODUCING AN ANTHRANILAMIDE COMPOUND ISHIHARA SANGYO KAISHA, LTD. (JP) 2010-12-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110034696-A1 PROCESS FOR PRODUCING ANTHRANILAMIDE COMPOUND SQOR, NOX5, NOX3 MALT1 3967/4885TYK2 1145/4885KMT2A 773/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.