Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MME | P08473 | 5/20 | 0.44 |
| ▸ | ACE | P12821 | 4/20 | 0.44 |
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.44 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | MMP14 | P50281 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | CPA1 | P15085 | 2/20 | 0.41 |
| ▸ | SRR | Q9GZT4 | 2/20 | 0.40 |
| ▸ | PSAT1 | Q9Y617 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | GHSR | Q92847 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2500069 | 0.92 | HPGD (0.48) | ALDH1A1MAPTADAMTS5MMP9MMP8 | |
| SCHEMBL28932692 | 0.92 | HPGD (0.48) | ALDH1A1MAPTADAMTS5MMP9MMP8 | |
| SCHEMBL2501195 | 0.86 | SLC7A5 (0.41) | TAAR1HPGD | |
| SCHEMBL2492807 | 0.83 | MAOB (0.53) | MMP9MMP8PPARGPPARAFFAR1 | |
| SCHEMBL21526204 | 0.78 | FAAH (0.44) | ALDH1A1MAPTADAMTS5MMP9MMP8 | |
| SCHEMBL1126593 | 0.78 | FAAH (0.44) | ALDH1A1MAPTADAMTS5MMP9MMP8 | |
| SCHEMBL28656503 | 0.78 | CYP1A2 (0.47) | ALDH1A1MAPTADAMTS5CPA1SRR | |
| SCHEMBL16932216 | 0.78 | MME (0.46) | ALDH1A1MAPTMMEACEACE2 | |
| SCHEMBL16932215 | 0.78 | MME (0.46) | ALDH1A1MAPTMMEACEACE2 | |
| SCHEMBL18554251 | 0.77 | MME (0.41) | ALDH1A1MAPTMMEACEACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8481732-B2 | Substituted heterocyclic compounds | INCYTE CORPORATION (US) | 2013-07-09 | — | — | US | disclosed |