Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11311385 | 0.81 | MAPK1 (0.64) | LMNANPC1RAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL27743102 | 0.80 | MAPK1 (0.48) | LMNAGAANPC1RAB9AMEN1 | |
| SCHEMBL14026892 | 0.79 | ELOVL1 (0.72) | LMNANPC1RAB9AMEN1KMT2A | |
| SCHEMBL27743104 | 0.78 | ALDH1A1 (0.58) | MEN1KMT2AALDH1A1KDM4EELOVL1 | |
| SCHEMBL3816209 | 0.75 | NPC1 (0.49) | LMNAGAANPC1RAB9AMEN1 | |
| SCHEMBL3813898 | 0.75 | NPC1 (0.49) | LMNAGAANPC1RAB9AMEN1 | |
| SCHEMBL3813895 | 0.75 | NPC1 (0.49) | LMNAGAANPC1RAB9AMEN1 | |
| SCHEMBL1355755 | 0.75 | CYP1A2 (0.59) | LMNAGAANPC1RAB9AKMT2A | |
| SCHEMBL7301734 | 0.73 | SMN1; SMN2 (0.67) | LMNAGAANPC1RAB9AMEN1 | |
| SCHEMBL1358311 | 0.72 | KDM4E (0.67) | LMNAGAANPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8481577-B2 | Amide thiazole derivative, preparation method and uses thereof | TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH (CN) | 2013-07-09 | — | — | US | disclosed |