Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.39 |
| ▸ | MAT2A | P31153 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 5/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 5/20 | 0.32 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | USP9X | Q93008 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21301422 | 0.85 | HRH3 (0.40) | HRH3MAT2AHTR6TLR9TLR7 | |
| SCHEMBL15086353 | 0.79 | TLR9 (0.41) | HRH3HTR6TLR9TLR7ADCY5 | |
| SCHEMBL15086519 | 0.79 | HRH3 (0.36) | HRH3HTR6HDAC4 | |
| SCHEMBL21301420 | 0.75 | HRH3 (0.35) | HRH3MAT2AHTR6TLR9TLR7 | |
| SCHEMBL15069100 | 0.74 | HRH3 (0.40) | HRH3MAT2AHTR6TLR9TLR7 | |
| SCHEMBL15086289 | 0.70 | HTR6 (0.37) | HRH3HTR6HDAC4ADCY5CTSS | |
| SCHEMBL16844842 | 0.70 | HTR6 (0.38) | HRH3HTR6TLR9TLR7HDAC4 | |
| SCHEMBL15086342 | 0.69 | HTR6 (0.36) | HRH3HTR6HDAC4ADCY5 | |
| SCHEMBL15086513 | 0.69 | TLR9 (0.38) | HTR6TLR9TLR7 | |
| SCHEMBL15086241 | 0.68 | HRH4 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013101974-A1 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | PTC THERAPEUTICS, INC. (US) | 2013-07-04 | — | — | WO | disclosed |