Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 5/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.33 |
| ▸ | CTSS | P25774 | 3/20 | 0.32 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.31 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.31 |
| ▸ | OGG1 | O15527 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16669739 | 0.77 | HTR6 (0.41) | HTR6HRH3ADRA2AADRA2BADRA2C | |
| SCHEMBL15069005 | 0.77 | HTR6 (0.41) | HTR6HRH3ADRA2AADRA2BADRA2C | |
| SCHEMBL15086353 | 0.74 | TLR9 (0.41) | HTR6HRH3CTSSADCY5OGG1 | |
| SCHEMBL15086519 | 0.73 | HRH3 (0.36) | HTR6HRH3ADRA2AADRA2BADRA2C | |
| SCHEMBL16844842 | 0.71 | HTR6 (0.38) | HTR6HRH3ADRA2AADRA2BADRA2C | |
| SCHEMBL15086359 | 0.70 | HRH3 (0.39) | HTR6HRH3HDAC4CTSSADCY5 | |
| SCHEMBL15086342 | 0.70 | HTR6 (0.36) | HTR6HRH3HDAC4ADCY5 | |
| SCHEMBL15086464 | 0.68 | — | — | |
| SCHEMBL21301465 | 0.68 | KDM4E (0.38) | HTR6ADRA2AADRA2BADRA2CHRH4 | |
| SCHEMBL16844846 | 0.66 | TLR9 (0.36) | HRH3PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013101974-A1 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | PTC THERAPEUTICS, INC. (US) | 2013-07-04 | — | — | WO | disclosed |