Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.62 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 4/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25484229 | 0.91 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2NPBWR1MCHR1KDM4E | |
| SCHEMBL31039463 | 0.88 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2NPBWR1MCHR1KDM4E | |
| SCHEMBL8246277 | 0.87 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2NPBWR1MCHR1KDM4E | |
| SCHEMBL9945954 | 0.86 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2NPBWR1MCHR1KDM4E | |
| SCHEMBL14970554 | 0.84 | ALDH1A1 (0.85) | ALDH1A1SMN1; SMN2NPBWR1MCHR1KDM4E | |
| SCHEMBL6481497 | 0.84 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2NPBWR1MCHR1KDM4E | |
| SCHEMBL9500070 | 0.84 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2NPBWR1MCHR1KDM4E | |
| SCHEMBL1913594 | 0.84 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2NPBWR1MCHR1KDM4E | |
| SCHEMBL23611294 | 0.84 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2NPBWR1MCHR1KDM4E | |
| SCHEMBL19000487 | 0.84 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2NPBWR1MCHR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130172342-A1 | BENZIMIDAZOLE DERIVATIVES AS SELECTIVE BLOCKERS OF PERSISTENT SODIUM CURRENT | ALLERGAN, INC. (US) | 2013-07-04 | — | — | US | disclosed |
| WO-2013101926-A1 | BENZIMIDAZOLE DERIVATIVES AS SELECTIVE BLOCKERS OF PERSISTENT SODIUM CURRENT | ALLERGAN, INC. (US) | 2013-07-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130172342-A1 | BENZIMIDAZOLE DERIVATIVES AS SELECTIVE BLOCKERS OF PERSISTENT SODIUM CURRENT | SCN1B, SCN2B, SCN1A | ALDH1A1 942/4885SMN1; SMN2 220/4885NPBWR1 631/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.