Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.44 |
| ▸ | ATM | Q13315 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12952630 | 0.90 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2NPBWR1MCHR1MAPT | |
| SCHEMBL9945918 | 0.87 | L3MBTL1 (0.46) | ALDH1A1SMN1; SMN2NPBWR1MCHR1MAPT | |
| SCHEMBL12907122 | 0.86 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2NPBWR1MCHR1MAPT | |
| SCHEMBL16952284 | 0.86 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2NPBWR1MCHR1MAPT | |
| SCHEMBL15086403 | 0.86 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2NPBWR1MCHR1MAPT | |
| SCHEMBL18959732 | 0.84 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2NPBWR1MCHR1KDM4E | |
| SCHEMBL18959733 | 0.84 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2NPBWR1MCHR1MAPT | |
| SCHEMBL12889916 | 0.82 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2MAPTPOLBKDM4E | |
| SCHEMBL23901711 | 0.81 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2NPBWR1MCHR1MAPT | |
| SCHEMBL9945953 | 0.81 | HTR2A (0.46) | ALDH1A1MAPTPOLBKDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149693-A1 | THERAPEUTIC COMPOUNDS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149693-A1 | THERAPEUTIC COMPOUNDS | HTR2C, GRK2, GRK3 | ALDH1A1 4010/4885SMN1; SMN2 3273/4885NPBWR1 1689/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.