Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | STAT1 | P42224 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14553703 | 0.94 | SMN1; SMN2 (0.54) | SMN1; SMN2RAB9ANPC1TP53PKM | |
| SCHEMBL14553543 | 0.86 | ALDH1A1 (0.46) | SMN1; SMN2RAB9ANPC1MAPTKMT2A | |
| SCHEMBL14484361 | 0.86 | NR1H4 (0.42) | SMN1; SMN2RAB9ANPC1TP53MAPT | |
| SCHEMBL14553656 | 0.84 | KMT2A (0.41) | SMN1; SMN2RAB9ANPC1TP53PKM | |
| SCHEMBL15088313 | 0.84 | MAPT (0.57) | SMN1; SMN2RAB9ANPC1TP53PKM | |
| SCHEMBL14553623 | 0.84 | MAOB (0.43) | SMN1; SMN2MAPTKMT2ALMNAALDH1A1 | |
| SCHEMBL14553652 | 0.83 | HTT (0.45) | SMN1; SMN2RAB9AMAPTKMT2ALMNA | |
| SCHEMBL27958547 | 0.83 | MAPT (0.49) | NPC1TP53MAPTKMT2ALMNA | |
| SCHEMBL14484348 | 0.82 | MAOB (0.41) | SMN1; SMN2RAB9AMAPTLMNAALDH1A1 | |
| SCHEMBL14484428 | 0.82 | POLB (0.44) | TP53MAPTKMT2ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170368030-A1 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2017-12-28 | — | — | US | disclosed |
| US-9775830-B2 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2017-10-03 | — | — | US | disclosed |
| US-9775830-B2 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2017-10-03 | — | — | US | disclosed |
| US-20170071910-A1 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2017-03-16 | — | — | US | disclosed |
| US-20170071910-A1 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2017-03-16 | — | — | US | disclosed |
| US-9517227-B2 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2016-12-13 | — | — | US | disclosed |
| US-9517227-B2 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2016-12-13 | — | — | US | disclosed |
| US-20140296238-A1 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2014-10-02 | — | — | US | disclosed |
| US-20140296238-A1 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2014-10-02 | — | — | US | disclosed |
| US-8791114-B2 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2014-07-29 | — | — | US | disclosed |
| US-8791114-B2 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2014-07-29 | — | — | US | disclosed |
| US-20130172351-A1 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2013-07-04 | — | — | US | disclosed |
| US-20130172351-A1 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2013-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170368030-A1 | Dihydropyrazoles | FSHR, GNRHR, LHCGR | SMN1; SMN2 3843/4885RAB9A 2196/4885NPC1 4269/4885 |
| US-20130172351-A1 | Dihydropyrazoles | FSHR, GNRHR, LHCGR | SMN1; SMN2 3843/4885RAB9A 2196/4885NPC1 4269/4885 |
| US-20140296238-A1 | Dihydropyrazoles | FSHR, GNRHR, LHCGR | SMN1; SMN2 3843/4885RAB9A 2196/4885NPC1 4269/4885 |
| US-20170071910-A1 | Dihydropyrazoles | FSHR, GNRHR, LHCGR | SMN1; SMN2 3843/4885RAB9A 2196/4885NPC1 4269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.