Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | TP53 | P04637 | 3/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15086784 | 0.84 | SMN1; SMN2 (0.49) | MAPTKMT2ATHRBNPC1RAB9A | |
| SCHEMBL15088298 | 0.82 | MAPT (0.58) | MAPTKMT2ATHRBNPC1RAB9A | |
| SCHEMBL15088296 | 0.81 | MAPT (0.60) | MAPTKMT2ATHRBNPC1RAB9A | |
| SCHEMBL15088324 | 0.81 | MAPT (0.48) | MAPTKMT2ASMN1; SMN2MEN1L3MBTL1 | |
| SCHEMBL14553656 | 0.78 | KMT2A (0.41) | MAPTKMT2ATHRBNPC1RAB9A | |
| SCHEMBL14553703 | 0.78 | SMN1; SMN2 (0.54) | MAPTKMT2ANPC1RAB9ATP53 | |
| SCHEMBL14553543 | 0.72 | ALDH1A1 (0.46) | MAPTKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14484483 | 0.72 | POLB (0.48) | MAPTKMT2ARAB9AMEN1MAPK1 | |
| SCHEMBL4328270 | 0.72 | MAPT (0.51) | MAPTKMT2ATHRBNPC1RAB9A | |
| SCHEMBL14487242 | 0.71 | KMT2A (0.52) | MAPTKMT2AMAPK1POLBCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9775830-B2 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2017-10-03 | — | — | US | disclosed |
| US-20170071910-A1 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2017-03-16 | — | — | US | disclosed |
| US-9517227-B2 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2016-12-13 | — | — | US | disclosed |
| US-20140296238-A1 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2014-10-02 | — | — | US | disclosed |
| US-8791114-B2 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2014-07-29 | — | — | US | disclosed |
| US-20130172351-A1 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2013-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130172351-A1 | Dihydropyrazoles | FSHR, GNRHR, LHCGR | MAPT 4055/4885KMT2A 2373/4885THRB 438/4885 |
| US-20140296238-A1 | Dihydropyrazoles | FSHR, GNRHR, LHCGR | MAPT 4055/4885KMT2A 2373/4885THRB 438/4885 |
| US-20170071910-A1 | Dihydropyrazoles | FSHR, GNRHR, LHCGR | MAPT 4055/4885KMT2A 2373/4885THRB 438/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.