SCHEMBL15087243

SCHEMBL15087243

C=Cc1ccc(C(C)(C)c2ccc(N(c3ccc(-c4ccc(N(c5ccc(C(C)(C)c6ccc(C=C)cc6)cc5)c5ccc6ccccc6c5)cc4)cc3)c3ccc4ccccc4c3)cc2)cc1

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.32
CYP2D6 P10635 1/20 0.32
SLC6A2 P23975 1/20 0.32
SLC6A4 P31645 1/20 0.32
SLC6A3 Q01959 1/20 0.32
KCNH2 Q12809 1/20 0.32
RELA Q04206 1/20 0.31
ESR1 P03372 1/20 0.31
ESR2 Q92731 1/20 0.31
ALDH1A1 P00352 3/20 0.31
SMN1; SMN2 Q16637 2/20 0.31
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
HDAC2 Q92769 1/20 0.31
CHRNB2 P17787 1/20 0.31
CHRNB4 P30926 1/20 0.31
CHRNA3 P32297 1/20 0.31
CHRNA7 P36544 1/20 0.31
CHRNA4 P43681 1/20 0.31
TSHR P16473 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15087284 0.97 CYP3A4 (0.33) CYP3A4CYP2D6SLC6A2SLC6A4SLC6A3
SCHEMBL23635765 0.89 RELA (0.38) CYP3A4RELAESR1ESR2ALDH1A1
SCHEMBL13829339 0.86 RELA (0.40) RELAESR1ESR2ALDH1A1SMN1; SMN2
SCHEMBL10165994 0.84 ALDH1A1 (0.41) CYP3A4RELAALDH1A1SMN1; SMN2MEN1
SCHEMBL15087288 0.82 CNR1 (0.40) CYP3A4SLC6A2SLC6A4ESR1ESR2
SCHEMBL15087336 0.82 ALDH1A1 (0.38) CYP3A4CYP2D6RELAESR1ESR2
SCHEMBL15087293 0.82 ALDH1A1 (0.38) CYP3A4CYP2D6RELAESR1ESR2
SCHEMBL15087322 0.82 TP53 (0.41) ESR1ESR2
SCHEMBL14854548 0.81 ALDH1A1 (0.43) CYP3A4CYP2D6RELAALDH1A1SMN1; SMN2
SCHEMBL15087337 0.81 ALDH1A1 (0.43) CYP3A4CYP2D6SLC6A2SLC6A4SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2797871-B1 CROSSLINKABLE ARYLAMINE COMPOUNDS NISSAN CHEMICAL IND LTD (JP) 2018-05-09 EP disclosed
US-20150094437-A1 CROSSLINKABLE ARYLAMINE COMPOUNDS NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2015-04-02 US disclosed
US-20150094437-A1 CROSSLINKABLE ARYLAMINE COMPOUNDS NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2015-04-02 US disclosed
WO-2013098175-A1 CROSSLINKABLE ARYLAMINE COMPOUNDS SOLVAY SA (BE) 2013-07-04 WO disclosed
EP-2610240-A1 Crosslinkable arylamine compounds SOLVAY SA (BE) 2013-07-03 EP disclosed