SCHEMBL1508977

SCHEMBL1508977

O=C(O)CNC(=O)c1nc(Cl)c2ccc(OCc3ccccc3)cc2c1O

nearest known ligand 0.69

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
THRA P10827 14/20 0.69
THRB P10828 14/20 0.69
EGLN1 Q9GZT9 9/20 0.69
BBOX1 O75936 2/20 0.65
FTO Q9C0B1 2/20 0.65
SLC6A2 P23975 1/20 0.56
SLC6A3 Q01959 1/20 0.56
ASPH Q12797 1/20 0.56
KDM8 Q8N371 1/20 0.56
EGLN2 Q96KS0 2/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30004549 1.00 THRA (0.69) THRATHRBEGLN1BBOX1FTO
SCHEMBL1509116 0.96 THRA (0.75) THRATHRBEGLN1BBOX1FTO
SCHEMBL30004356 0.96 THRA (0.75) THRATHRBEGLN1BBOX1FTO
SCHEMBL4081493 0.89 THRA (0.56) THRATHRBEGLN1BBOX1FTO
SCHEMBL522875 0.88 THRA (0.64) THRATHRBEGLN1BBOX1FTO
SCHEMBL31028948 0.88 THRA (0.64) THRATHRBEGLN1BBOX1FTO
SCHEMBL522871 0.87 EGLN1 (0.49) THRATHRBEGLN1BBOX1FTO
SCHEMBL523521 0.86 THRA (0.91) THRATHRBEGLN1BBOX1FTO
SCHEMBL1656320 0.85 EGLN2 (0.75) EGLN1EGLN2
SCHEMBL4075898 0.85 THRA (0.55) THRATHRBEGLN1BBOX1FTO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150080425-A1 METHODS FOR TREATING ANEMIA IN SUBJECTS HAVING KIDNEY FAILURE USING INHIBITORS OF HYPOXIA-INDUCIBLE FACTOR (HIF) HYDROXYLASE FIBROGEN, INC. (US) 2015-03-19 US claimed
EP-1463823-B1 METHODS OF INCREASING ENDOGENOUS ERYTHROPOIETIN (EPO) FIBROGEN INC (US) 2013-03-06 EP claimed
US-20060178316-A1 Methods of increasing endogenous erythropoietin (EPO) FIBROGEN, INC. (US) 2006-08-10 US claimed
EP-2298301-B2 MEDICAMENTS FOR TREATING ANEMIA ASSOCIATED WITH KIDNEY DISEASE FIBROGEN INC (US) 2022-11-16 EP disclosed
US-20210369702-A1 METHODS FOR TREATING ANEMIA IN SUBJECTS HAVING KIDNEY FAILURE USING INHIBITORS OF HYPOXIA-INDUCIBLE FACTOR (HIF) HYDROXYLASE FIBROGEN, INC. (US) 2021-12-02 US disclosed
EP-3520784-A1 HIF PROLYL HYDROXYLASE INHIBITOR FOR TREATMENT OF ANEMIA Fibrogen, Inc. (US) 2019-08-07 EP disclosed
EP-2324834-B1 Methods of Increasing Endogenous Erythropoietin (EPO) FIBROGEN INC (US) 2019-05-08 EP disclosed
EP-2298301-B1 MEDICAMENTS FOR TREATING ANEMIA ASSOCIATED WITH KIDNEY DISEASE FIBROGEN INC (US) 2018-07-04 EP disclosed
EP-2289531-B1 Medicaments for the treatment or prevention of anemia FIBROGEN INC (US) 2018-07-04 EP disclosed
US-20170312268-A1 METHODS FOR TREATING A NEUROLOGICAL DISORDER IN A SUBJECT USING INHIBITORS OF HYPOXIA-INDUCIBLE FACTOR (HIF) PROYL HYDROXYLASE FIBROGEN, INC. (US) 2017-11-02 US disclosed
US-20150080425-A1 METHODS FOR TREATING ANEMIA IN SUBJECTS HAVING KIDNEY FAILURE USING INHIBITORS OF HYPOXIA-INDUCIBLE FACTOR (HIF) HYDROXYLASE FIBROGEN, INC. (US) 2015-03-19 US disclosed
US-20060178317-A1 Methods of increasing endogenous erythropoietin (EPO) FIBROGEN, INC. (US) 2006-08-10 US disclosed
EP-1463823-A4 METHODS OF INCREASING ENDOGENOUS ERYTHROPOIETIN (EPO) FIBROGEN INC (US) 2005-11-16 EP disclosed
EP-0911340-B1 Substituted Isoquinolin-3-Carboxyamides, their preparation and medical use FIBROGEN INC (US) 2005-07-06 EP disclosed
EP-1538160-A1 Substituted Isoquinolin-3-carboxyamides, their preparation and medical use FIBROGEN, INC. (US) 2005-06-08 EP disclosed
EP-1463823-A2 METHODS OF INCREASING ENDOGENOUS ERYTHROPOIETIN (EPO) FIBROGEN, INC. (US) 2004-10-06 EP disclosed
US-20030153503-A1 Methods of increasing endogenous erythropoietin (EPO) FIBROGEN, INC. 2003-08-14 US disclosed
WO-2003053997-A2 METHODS OF INCREASING ENDOGENOUS ERYTHROPOIETIN (EPO) FIBROGEN, INC. (US) 2003-07-03 WO disclosed
US-6093730-A AN ENZYME INHIBITORS OF PROLYL-4-HYDROXYLASE FOR TREATING FIBROTIC DISORDERS AND INHIBITING COLLAGEN BIOSYNTHESIS HOECHST MARION ROUSSEL DEUTSCHLAND GMBH (DE) 2000-07-25 US disclosed
EP-0911340-A2 Substituted Isoquinolin-3-Carboxyamides, their preparation and medical use Hoechst Marion Roussel Deutschland GmbH (DE) 1999-04-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150080425-A1 METHODS FOR TREATING ANEMIA IN SUBJECTS HAVING KIDNEY FAILURE USING INHIBITORS OF HYPOXIA-INDUCIBLE FACTOR (HIF) HYDROXYLASE HIF1AN, HIF1A, EGLN2 THRA 1520/4885THRB 1669/4885EGLN1 5/4885
US-20060178317-A1 Methods of increasing endogenous erythropoietin (EPO) EPOR, EGLN3, EGLN2 THRA 2906/4885THRB 2553/4885EGLN1 13/4885
US-20210369702-A1 METHODS FOR TREATING ANEMIA IN SUBJECTS HAVING KIDNEY FAILURE USING INHIBITORS OF HYPOXIA-INDUCIBLE FACTOR (HIF) HYDROXYLASE HIF1AN, HIF1A, EGLN2 THRA 1520/4885THRB 1669/4885EGLN1 5/4885
US-20170312268-A1 METHODS FOR TREATING A NEUROLOGICAL DISORDER IN A SUBJECT USING INHIBITORS OF HYPOXIA-INDUCIBLE FACTOR (HIF) PROYL HYDROXYLASE HIF1AN, EGLN2, EGLN3 THRA 2211/4885THRB 2231/4885EGLN1 9/4885
US-20030153503-A1 Methods of increasing endogenous erythropoietin (EPO) EPOR, EGLN3, EGLN2 THRA 2906/4885THRB 2553/4885EGLN1 13/4885
US-20060178316-A1 Methods of increasing endogenous erythropoietin (EPO) EPOR, EGLN3, EGLN2 THRA 2906/4885THRB 2553/4885EGLN1 13/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.