Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 13/20 | 0.55 |
| ▸ | THRB | P10828 | 13/20 | 0.55 |
| ▸ | EGLN1 | Q9GZT9 | 8/20 | 0.55 |
| ▸ | BBOX1 | O75936 | 2/20 | 0.51 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.51 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | ASPH | Q12797 | 1/20 | 0.47 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4070358 | 0.91 | THRA (0.56) | THRATHRBEGLN1BBOX1FTO | |
| SCHEMBL4081493 | 0.90 | THRA (0.56) | THRATHRBEGLN1BBOX1FTO | |
| SCHEMBL4071786 | 0.88 | THRA (0.59) | THRATHRBEGLN1BBOX1FTO | |
| SCHEMBL4075055 | 0.86 | EGLN2 (0.52) | THRATHRBEGLN1EGLN2KMT2A | |
| SCHEMBL30004549 | 0.85 | THRA (0.69) | THRATHRBEGLN1BBOX1FTO | |
| SCHEMBL1508977 | 0.85 | THRA (0.69) | THRATHRBEGLN1BBOX1FTO | |
| SCHEMBL4080194 | 0.84 | EGLN1 (0.51) | THRATHRBEGLN1BBOX1FTO | |
| SCHEMBL522745 | 0.83 | THRA (0.70) | THRATHRBEGLN1BBOX1FTO | |
| SCHEMBL522867 | 0.83 | THRA (0.64) | THRATHRBEGLN1BBOX1FTO | |
| SCHEMBL522875 | 0.83 | THRA (0.64) | THRATHRBEGLN1BBOX1FTO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1538160-B1 | Substituted Isoquinolin-3-carboxyamides, their preparation and medical use | FIBROGEN INC (US) | 2009-06-03 | — | — | EP | disclosed |
| EP-0911340-B1 | Substituted Isoquinolin-3-Carboxyamides, their preparation and medical use | FIBROGEN INC (US) | 2005-07-06 | — | — | EP | disclosed |
| EP-1538160-A1 | Substituted Isoquinolin-3-carboxyamides, their preparation and medical use | FIBROGEN, INC. (US) | 2005-06-08 | — | — | EP | disclosed |
| US-6093730-A | AN ENZYME INHIBITORS OF PROLYL-4-HYDROXYLASE FOR TREATING FIBROTIC DISORDERS AND INHIBITING COLLAGEN BIOSYNTHESIS | HOECHST MARION ROUSSEL DEUTSCHLAND GMBH (DE) | 2000-07-25 | — | — | US | disclosed |
| EP-0911340-A2 | Substituted Isoquinolin-3-Carboxyamides, their preparation and medical use | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-04-28 | — | — | EP | disclosed |