SCHEMBL15089976

SCHEMBL15089976

Cc1cccc(C)c1OCCI

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.50
SCN4A P35499 8/20 0.48
SCN8A Q9UQD0 5/20 0.48
LMNA P02545 3/20 0.48
SCN1A P35498 2/20 0.48
SCN5A Q14524 2/20 0.48
SCN9A Q15858 2/20 0.48
CYP1A2 P05177 2/20 0.48
CYP3A4 P08684 2/20 0.48
CYP2D6 P10635 2/20 0.48
NFKB1 P19838 2/20 0.48
CYP2C9 P11712 1/20 0.48
TSHR P16473 1/20 0.48
KCNK3 O14649 1/20 0.48
CACNA1F O60840 1/20 0.48
KCNK2 O95069 1/20 0.48
GBA1 P04062 1/20 0.48
MAOA P21397 1/20 0.48
HTR2A P28223 1/20 0.48
SLC6A4 P31645 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18727141 0.81 SCN4A (0.52) ALDH1A1SCN4ASCN8ALMNASCN1A
SCHEMBL1991553 0.79 ALDH1A1 (0.52) ALDH1A1SCN4ASCN8ALMNASCN1A
SCHEMBL2094083 0.78 SCN4A (0.54) ALDH1A1SCN4ASCN8ALMNASCN1A
SCHEMBL9201467 0.77 SCN4A (0.55) ALDH1A1SCN4ASCN8ALMNASCN1A
SCHEMBL5824885 0.77 ALDH1A1 (0.50) ALDH1A1SCN4ASCN8ALMNASCN1A
SCHEMBL64093 0.77 ALDH1A1 (0.50) ALDH1A1SCN4ASCN8ALMNASCN1A
Ammonia Solution, Strong SCHEMBL8858388 0.77 ALDH1A1 (0.50) ALDH1A1SCN4ASCN8ALMNASCN1A
SCHEMBL4382775 0.77 ALDH1A1 (0.55) ALDH1A1SCN4ASCN8ALMNASCN1A
SCHEMBL6373909 0.77 ALDH1A1 (0.55) ALDH1A1SCN4ASCN8ALMNASCN1A
SCHEMBL515980 0.77 ALDH1A1 (0.61) ALDH1A1SCN4ASCN8ALMNASCN1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013101911-A2 BENZIMIDAZOLE DERIVATIVES AS SELECTIVE BLOCKERS OF PERSISTENT SODIUM CURRENT ALLERGAN, INC. (US) 2013-07-04 WO disclosed