Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | SCN4A | P35499 | 8/20 | 0.48 |
| ▸ | SCN8A | Q9UQD0 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | SCN1A | P35498 | 2/20 | 0.48 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.48 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.48 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.48 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.48 |
| ▸ | GBA1 | P04062 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10768133 | 0.89 | ALDH1A1 (0.53) | ALDH1A1SCN4ASCN8ALMNASCN1A | |
| SCHEMBL4743329 | 0.85 | ALDH1A1 (0.56) | ALDH1A1SCN4ASCN8ALMNASCN1A | |
| SCHEMBL23804886 | 0.82 | TSHR (0.46) | ALDH1A1SCN4ASCN8ALMNASCN1A | |
| SCHEMBL287638 | 0.81 | SCN4A (0.52) | ALDH1A1SCN4ASCN8ALMNASCN1A | |
| SCHEMBL1770541 | 0.80 | ALDH1A1 (0.41) | ALDH1A1SCN4ASCN8ALMNASCN5A | |
| SCHEMBL1991553 | 0.79 | ALDH1A1 (0.52) | ALDH1A1SCN4ASCN8ALMNASCN1A | |
| SCHEMBL5592615 | 0.77 | KMT2A (0.46) | ALDH1A1LMNAHTR2AKDM4EMEN1 | |
| Ammonia Solution, Strong SCHEMBL8858388 | 0.77 | ALDH1A1 (0.50) | ALDH1A1SCN4ASCN8ALMNASCN1A | |
| SCHEMBL15089976 | 0.77 | ALDH1A1 (0.50) | ALDH1A1SCN4ASCN8ALMNASCN1A | |
| SCHEMBL5824885 | 0.77 | ALDH1A1 (0.50) | ALDH1A1SCN4ASCN8ALMNASCN1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3938345-B1 | CHARGED ION CHANNEL BLOCKERS AND METHODS FOR USE | NOCION THERAPEUTICS INC (US) | 2026-05-06 | — | — | EP | disclosed |
| US-20250263386-A1 | Charged Ion Channel Blockers and Methods for Use | NOCION THERAPEUTICS INC (US) | 2025-08-21 | — | — | US | disclosed |
| US-20250263375-A1 | Charged Ion Channel Blockers and Methods for Use | NOCION THERAPEUTICS INC (US) | 2025-08-21 | — | — | US | disclosed |
| CN-119874561-A | Charged ion channel blockers and methods of use thereof | 诺西恩医疗公司 | 2025-04-25 | — | — | CN | disclosed |
| CN-113950471-B | Charged ion channel blockers and methods of use thereof | 诺西恩医疗公司 | 2025-01-14 | — | — | CN | disclosed |
| CN-119118953-A | Charged ion channel blockers and methods of use thereof | 诺西恩医疗公司 | 2024-12-13 | — | — | CN | disclosed |
| US-12162851-B2 | Charged ion channel blockers and methods for use | Nocion Therapeutics, Inc. (US) | 2024-12-10 | — | — | US | disclosed |
| CN-115279731-B | Charged ion channel blockers and methods of use thereof | 诺西恩医疗公司 | 2024-09-13 | — | — | CN | disclosed |
| US-20230192613-A1 | Charged Ion Channel Blockers and Methods for Use | NOCION THERAPEUTICS INC (US) | 2023-06-22 | — | — | US | disclosed |
| US-11603355-B2 | Charged ion channel blockers and methods for use | Nocion Therapeutics, Inc. (US) | 2023-03-14 | — | — | US | disclosed |
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | disclosed |
| EP-0232825-B1 | PYRIDAZINONE DERIVATIVES, PREPARATION THEREOF, AND INSECTICIDAL, ACARICIDAL, NEMATICIDAL, FUNGICIDAL COMPOSITIONS | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1992-05-13 | — | — | EP | disclosed |
| US-4906627-A | Pyridazinone derivatives, and insecticidal, acaricidal and nematicidal compositions | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 1990-03-06 | — | — | US | disclosed |
| EP-0232825-A2 | Pyridazinone derivatives, preparation thereof, and insecticidal, acaricidal, nematicidal, fungicidal compositions | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1987-08-19 | — | — | EP | disclosed |
| US-4259334-A | Piperazines and therapeutic utility | LAROCHE NAVARRON S.A. (FR) | 1981-03-31 | — | — | US | disclosed |
| US-4166117-A | HYPOTENSIVES | SCIENCE UNION ET CIE (FR) | 1979-08-28 | — | — | US | disclosed |
| US-4027028-A | HYPOTENSIVE AGENTS | SCIENCE UNION ET CIE (FR) | 1977-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12162851-B2 | Charged ion channel blockers and methods for use | TRPV1, TRPV5, TRPV2 | ALDH1A1 2437/4885SCN4A 83/4885SCN8A 142/4885 |
| US-20250263386-A1 | Charged Ion Channel Blockers and Methods for Use | TRPV1, TRPV5, TRPV2 | ALDH1A1 2437/4885SCN4A 83/4885SCN8A 142/4885 |
| US-20250263375-A1 | Charged Ion Channel Blockers and Methods for Use | TRPV1, TRPV2, TRPV5 | ALDH1A1 2736/4885SCN4A 80/4885SCN8A 107/4885 |
| US-11603355-B2 | Charged ion channel blockers and methods for use | TRPV1, TRPV2, TRPV5 | ALDH1A1 2736/4885SCN4A 80/4885SCN8A 107/4885 |
| US-20230192613-A1 | Charged Ion Channel Blockers and Methods for Use | TRPV1, TRPV2, TRPV5 | ALDH1A1 2736/4885SCN4A 80/4885SCN8A 107/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.