Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.32 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1508909 | 0.86 | KCNQ3 (0.37) | KCNQ3KCNQ2CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL3831124 | 0.83 | NPSR1 (0.34) | ALDH1A1SMN1; SMN2KCNQ3KCNQ2LMNA | |
| SCHEMBL3831127 | 0.83 | NPSR1 (0.34) | ALDH1A1SMN1; SMN2KCNQ3KCNQ2LMNA | |
| SCHEMBL2487546 | 0.83 | NPSR1 (0.34) | ALDH1A1SMN1; SMN2KCNQ3KCNQ2LMNA | |
| SCHEMBL1508736 | 0.80 | NPC1 (0.34) | PDE10AADAM17ADAMTS5NPC1POLB | |
| SCHEMBL1508733 | 0.78 | KMO (0.32) | PDE10AADAM17ADAMTS5ALDH1A1NPC1 | |
| SCHEMBL3827291 | 0.78 | NPSR1 (0.36) | ALDH1A1SMN1; SMN2KCNQ3KCNQ2CHRNB2 | |
| SCHEMBL3833887 | 0.78 | NPSR1 (0.36) | ALDH1A1SMN1; SMN2KCNQ3KCNQ2CHRNB2 | |
| SCHEMBL7943091 | 0.74 | ALDH1A1 (0.31) | ALDH1A1MAPT | |
| SCHEMBL1508787 | 0.70 | NPSR1 (0.36) | ALDH1A1GAAMAPTLMNACHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298778-A1 | IMIDAZOTHIAZOLE DERIVATIVE HAVING 4,7-DIAZASPIROÝ2.5¨OCTANE RING STRUCTURE | Daiichi Sankyo Company, Limited (JP) | 2011-03-23 | — | — | EP | disclosed |