⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3317344 | 0.72 | ALDH1A1 (0.32) | — | |
| SCHEMBL28875234 | 0.71 | — | — | |
| SCHEMBL3821371 | 0.70 | LMNA (0.41) | — | |
| SCHEMBL965458 | 0.69 | LMNA (0.34) | — | |
| SCHEMBL8561 | 0.69 | — | — | |
| SCHEMBL161337 | 0.69 | — | — | |
| SCHEMBL161336 | 0.69 | — | — | |
| SCHEMBL1857158 | 0.67 | — | — | |
| SCHEMBL24294078 | 0.67 | — | — | |
| SCHEMBL10861571 | 0.67 | PARP1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295976-A1 | Markers for colorectal cancer | Auvation Ltd (GB) | 2011-03-16 | — | — | EP | disclosed |
| US-20100216156-A1 | CANCER MARKERS | MURRAY GRAEME IAN | 2010-08-26 | — | — | US | disclosed |
| EP-0405370-B2 | Riboflavinoverproducing strains of bacteria | DSM IP ASSETS BV (NL) | 2007-12-19 | — | — | EP | disclosed |
| US-7091000-B2 | Bacterial strains which overproduce riboflavin and methods of use thereof | DSM NUTRITIONAL PRODUCTS, INC. (US) | 2006-08-15 | — | — | US | disclosed |
| US-20030232406-A1 | Bacterial strains which overproduce riboflavin | ROCHE VITAMINS, INC. | 2003-12-18 | — | — | US | disclosed |
| US-6551813-B1 | Yeast extract, glucose, a magnesium salt, a manganese salt, a calcium salt, an iron salt, a phosphate buffer, and additional salt selected from the group consisting of a glutamic acid salt, a citric acid salt, and a succinic acid salt | ROCHE VITAMINS INC. | 2003-04-22 | — | — | US | disclosed |
| US-6322995-B1 | RECOMBINANT GRAM POSITIVE BACTERIUM USED FOR PRODUCING RIBOFLAVIN | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-27 | — | — | US | disclosed |
| EP-0405370-B1 | Riboflavinoverproducing strains of bacteria | HOFFMANN LA ROCHE (CH) | 2000-08-30 | — | — | EP | disclosed |
| EP-1001026-A2 | Riboflavinoverproducing strains of bacteria | F. Hoffmann-La Roche AG (CH) | 2000-05-17 | — | — | EP | disclosed |
| US-5925538-A | CULTURING RECOMBINANT BACTERIUM HAVING EXOGENOUS NUCLEIC ACID SEQUENCE CODING FOR PROMOTER AND OPEN READING FRAME 3 STRUCTURAL GENE SIMILAR TO A BACILLUS SUBTILIS RIBOFLAVIN OPERON GENE, RECOVERING AT LEAST 10 GRAMS PER LITER | ROCHE VITAMINS INC. (US) | 1999-07-20 | — | — | US | disclosed |
| US-5837528-A | NUCLEOTIDE SEQUENCE OF RIB OPERON AND ITS OPEN READING FRAMES; GENETIC ENGINEERING | HOFFMANN LA ROCHE, INC. (US) | 1998-11-17 | — | — | US | disclosed |
| US-5800979-A | Gas chromatography/mass spectrometric determination of folic acid coenzymes | KOLHOUSE J FRED (US) | 1998-09-01 | — | — | US | disclosed |
| EP-0405370-A1 | Riboflavinoverproducing strains of bacteria | F. HOFFMANN-LA ROCHE AG (CH) | 1991-01-02 | — | — | EP | disclosed |