Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17675443 | 0.76 | LMNA (0.35) | LMNA | |
| SCHEMBL28875234 | 0.72 | — | — | |
| SCHEMBL1509205 | 0.69 | — | — | |
| SCHEMBL380631 | 0.67 | — | — | |
| SCHEMBL162854 | 0.67 | — | — | |
| SCHEMBL3821371 | 0.67 | LMNA (0.41) | LMNA | |
| SCHEMBL4242639 | 0.66 | — | — | |
| SCHEMBL3861670 | 0.66 | — | — | |
| SCHEMBL3398350 | 0.66 | — | — | |
| SCHEMBL17771224 | 0.66 | HCAR2 (0.38) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518954-B2 | Inhibitors of folic acid-dependent enzymes | STOICESCU DAN (CH) | 2013-08-27 | — | — | US | disclosed |
| US-7875716-B2 | Such as n-[4-[[2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]pseudoglutamic ester; synthesis; efficacy; reduced renal toxicity and other adverse side effects; cancer | STOICESCU DAN | 2011-01-25 | — | — | US | disclosed |
| US-20100249141-A1 | NOVEL INHIBITORS OF FOLIC ACID-DEPENDENT ENZYMES | STOICESCU DAN | 2010-09-30 | — | — | US | disclosed |
| US-7718660-B2 | Inhibitors of folic acid-dependent enzymes | STOICESCU DAN | 2010-05-18 | — | — | US | disclosed |
| US-20080214550-A1 | Novel inhibitors of folic acid-dependent enzymes | STOICESCU DAN | 2008-09-04 | — | — | US | disclosed |
| EP-1809292-B1 | CONDENSED PYRIMIDINE DERIVATIVES AS INHIBITORS OF FOIC ACID-DEPENDENT ENZYMES | STOICESCU DAN (CH) | 2008-05-21 | — | — | EP | disclosed |
| US-20070265444-A1 | Novel Inhibitors of Folic Acid-Dependent Enzymes | STOICESCU DAN | 2007-11-15 | — | — | US | disclosed |
| EP-1809292-A2 | CONDENSED PYRIMIDINE DERIVATIVES AS INHIBITORS OF FOIC ACID-DEPENDENT ENZYMES | Stoicescu, Dan (CH) | 2007-07-25 | — | — | EP | disclosed |
| WO-2007020277-A2 | CONDENSED PYRIMIDINE DERIVATIVES AS INHIBITORS OF FOIC ACID-DEPENDENT ENZYMES | STOICESCU DAN (CY) | 2007-02-22 | — | — | WO | disclosed |
| EP-1754484-A1 | Condensed pyrimidine derivatives as inhibitors of foic acid-dependent enzymes | Stoicescu, Dan (CY) | 2007-02-21 | — | — | EP | disclosed |
| EP-1482977-A1 | COMBINATION THERAPIES FOR TREATING METHYLTHIOADENOSINE PHOSPHORYLASE DEFICIENT CELLS | PFIZER INC. (US) | 2004-12-08 | — | — | EP | disclosed |
| US-20040043959-A1 | Combination therapies for treating methylthioadenosine phosphorylase deficient cells | AGOURON PHARMACEUTICALS INC. | 2004-03-04 | — | — | US | disclosed |
| WO-2003074083-A1 | COMBINATION THERAPIES FOR TREATING METHYLTHIOADENOSINE PHOSPHORYLASE DEFICIENT CELLS | PFIZER INC. (US) | 2003-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249141-A1 | NOVEL INHIBITORS OF FOLIC ACID-DEPENDENT ENZYMES | FOLR2, FOLR1, DHFR | LMNA 4222/4885 |
| US-20070265444-A1 | Novel Inhibitors of Folic Acid-Dependent Enzymes | FOLR2, FOLR1, DHFR | LMNA 4172/4885 |
| US-20080214550-A1 | Novel inhibitors of folic acid-dependent enzymes | FOLR2, FOLR1, DHFR | LMNA 4294/4885 |
| US-20040043959-A1 | Combination therapies for treating methylthioadenosine phosphorylase deficient cells | APRT, MTAP, TYMP | LMNA 3053/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.