Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD2 | O96028 | 1/20 | 0.48 |
| ▸ | GRM4 | Q14833 | 8/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | GRM8 | O00222 | 2/20 | 0.44 |
| ▸ | GRM6 | O15303 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.43 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cycloleucine SCHEMBL1704308 | 1.00 | NSD2 (0.48) | NSD2GRM4CYP2C19CYP1A2ALDH1A1 | |
| SCHEMBL59793 | 1.00 | NSD2 (0.48) | NSD2GRM4CYP2C19CYP1A2ALDH1A1 | |
| SCHEMBL8981098 | 1.00 | NSD2 (0.48) | NSD2GRM4CYP2C19CYP1A2ALDH1A1 | |
| SCHEMBL744894 | 1.00 | NSD2 (0.48) | NSD2GRM4CYP2C19CYP1A2ALDH1A1 | |
| SCHEMBL21423145 | 1.00 | NSD2 (0.48) | NSD2GRM4CYP2C19CYP1A2ALDH1A1 | |
| SCHEMBL60473 | 1.00 | NSD2 (0.48) | NSD2GRM4CYP2C19CYP1A2ALDH1A1 | |
| SCHEMBL62221 | 1.00 | NSD2 (0.48) | NSD2GRM4CYP2C19CYP1A2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL1321302 | 0.97 | NSD2 (0.46) | NSD2GRM4CYP2C19CYP1A2ALDH1A1 | |
| Methane SCHEMBL11142076 | 0.97 | NSD2 (0.46) | NSD2GRM4CYP2C19CYP1A2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL21497076 | 0.97 | NSD2 (0.46) | NSD2GRM4CYP2C19CYP1A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10787450-B2 | Spiro-fused cyclic ureas as inhibitors of rock | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-09-29 | — | — | US | disclosed |
| US-20190300528-A1 | SPIRO-FUSED CYCLIC UREAS AS INHIBITORS OF ROCK | BRISTOL MYERS SQUIBB CO (US) | 2019-10-03 | — | — | US | disclosed |
| US-8481725-B2 | Cycloalkylcarbonylamino acid derivative and process for producing the same | SEIKAGAKU CORPORATION (JP) | 2013-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10787450-B2 | Spiro-fused cyclic ureas as inhibitors of rock | MYLK, ROCK1, UACA | NSD2 3659/4885GRM4 4125/4885CYP2C19 3564/4885 |
| US-20190300528-A1 | SPIRO-FUSED CYCLIC UREAS AS INHIBITORS OF ROCK | MYLK, ROCK1, UACA | NSD2 3659/4885GRM4 4125/4885CYP2C19 3564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.