Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8388574 | 0.81 | GAA (0.54) | KMT2AMEN1THRBALDH1A1GAA | |
| SCHEMBL3819701 | 0.81 | KMT2A (0.71) | KMT2AMEN1THRBALDH1A1GAA | |
| SCHEMBL15096234 | 0.80 | HSD17B10 (0.36) | KMT2AMEN1ALDH1A1GAAHSD17B10 | |
| SCHEMBL15096235 | 0.80 | NAMPT (0.43) | KMT2AALDH1A1GAAHSD17B10SMN1; SMN2 | |
| SCHEMBL15096230 | 0.79 | HCAR2 (0.39) | KMT2AMEN1ALDH1A1GAAHSD17B10 | |
| SCHEMBL17108545 | 0.78 | ALDH1A1 (0.47) | KMT2AMEN1THRBALDH1A1GAA | |
| SCHEMBL9921622 | 0.75 | ALDH1A1 (0.52) | THRBALDH1A1GAAPLOD2HDAC1 | |
| SCHEMBL17788031 | 0.74 | THRB (0.57) | KMT2AMEN1THRBALDH1A1GAA | |
| SCHEMBL25804515 | 0.72 | LMNA (0.43) | KMT2AMEN1THRBALDH1A1PLOD2 | |
| SCHEMBL2628275 | 0.72 | ALDH1A1 (0.48) | THRBALDH1A1GAAPLOD2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8975232-B2 | Macrocyclic kinase inhibitors and uses thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-03-10 | — | — | US | disclosed |
| US-20130178429-A1 | MACROCYCLIC KINASE INHIBITORS AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130178429-A1 | MACROCYCLIC KINASE INHIBITORS AND USES THEREOF | MAP3K20, MAP3K11, MAP3K1 | KMT2A 845/4885MEN1 1368/4885THRB 1390/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.