Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | BPTF | Q12830 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | QDPR | P09417 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28001268 | 0.74 | — | — | |
| SCHEMBL19087029 | 0.71 | — | — | |
| SCHEMBL27394473 | 0.69 | — | — | |
| SCHEMBL11846574 | 0.67 | QDPR (0.41) | NOTUMALDH1A1KDM4EHSD17B10MAPT | |
| SCHEMBL18269036 | 0.67 | NOTUM (0.39) | NOTUMKDM4EMAPTHTTMEN1 | |
| SCHEMBL13900837 | 0.67 | NOTUM (0.39) | NOTUMALDH1A1KDM4EHSD17B10MAPT | |
| SCHEMBL13536722 | 0.63 | CYP3A4 (0.40) | NOTUMALDH1A1KDM4EHSD17B10MAPT | |
| SCHEMBL8163530 | 0.63 | ALDH1A1 (0.49) | NOTUMALDH1A1KDM4EHSD17B10MAPT | |
| SCHEMBL13804073 | 0.63 | QDPR (0.47) | NOTUMBPTFQDPRCYP1A2CASP6 | |
| SCHEMBL26987762 | 0.63 | QDPR (0.47) | NOTUMALDH1A1KDM4EHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10428019-B2 | Chiral auxiliaries | WAVE LIFE SCIENCES LTD. (SG) | 2019-10-01 | — | — | US | disclosed |
| EP-2620428-A1 | ASYMMETRIC AUXILIARY GROUP | Chiralgen, Ltd. (JP) | 2013-07-31 | — | — | EP | disclosed |
| US-20130178612-A1 | CHIRAL AUXILIARIES | CHIRALGEN, LTD. (JP) | 2013-07-11 | — | — | US | disclosed |
| US-20130178612-A1 | CHIRAL AUXILIARIES | CHIRALGEN, LTD. (JP) | 2013-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130178612-A1 | CHIRAL AUXILIARIES | POLL, PCNA, POLM | NOTUM 4217/4885ALDH1A1 3045/4885KDM4E 4672/4885 |
| US-10428019-B2 | Chiral auxiliaries | PCNA, POLL, TYMP | NOTUM 3003/4885ALDH1A1 2263/4885KDM4E 4634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.