Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 4/20 | 0.45 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16448854 | 0.79 | MEN1 (0.36) | HPGDLMNAGAAMEN1KMT2A | |
| SCHEMBL13711952 | 0.78 | ALDH1A1 (0.50) | HPGDTSHRGAATDP1MEN1 | |
| SCHEMBL2207140 | 0.78 | HPGD (0.54) | HPGDLMNATSHRGAAACHE | |
| SCHEMBL3888438 | 0.74 | HPGD (0.70) | HPGDLMNATSHRGAAACHE | |
| SCHEMBL1727115 | 0.74 | HPGD (1.00) | HPGDLMNATSHRGAAACHE | |
| SCHEMBL12585405 | 0.73 | HPGD (0.54) | HPGDLMNATSHRGAAACHE | |
| SCHEMBL12584873 | 0.73 | HPGD (0.54) | HPGDLMNATSHRGAAACHE | |
| SCHEMBL262688 | 0.71 | HPGD (0.65) | HPGDLMNATSHRGAAACHE | |
| SCHEMBL5435185 | 0.71 | HPGD (0.65) | HPGDLMNATSHRGAAACHE | |
| SCHEMBL27614826 | 0.70 | LMNA (0.68) | HPGDLMNATSHRGAAACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8486994-B2 | Prodrugs of substituted 1,3-dioxanes and their uses | EVOLVA SA (CH) | 2013-07-16 | — | — | US | disclosed |