Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 4/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.35 |
| ▸ | APP | P05067 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7998877 | 0.78 | MCHR1 (0.36) | CYP11B1CYP11B2APPALDH1A1SMN1; SMN2 | |
| SCHEMBL17810161 | 0.76 | MCHR1 (0.34) | CYP11B1CYP11B2APPDRD2DRD4 | |
| SCHEMBL22363049 | 0.75 | USP7 (0.40) | CYP11B1CYP11B2APP | |
| SCHEMBL17810219 | 0.75 | PDE10A (0.34) | CYP11B1CYP11B2APPKDM4EALDH1A1 | |
| SCHEMBL15111001 | 0.74 | APP (0.33) | CYP11B1CYP11B2APP | |
| SCHEMBL16160303 | 0.72 | ALDH1A1 (0.36) | CYP11B1CYP11B2APPKDM4EALDH1A1 | |
| SCHEMBL17810131 | 0.72 | APP (0.32) | CYP11B1CYP11B2APPALDH1A1 | |
| SCHEMBL1500061 | 0.72 | MCHR1 (0.41) | CYP11B1CYP11B2APPKDM4ESMN1; SMN2 | |
| SCHEMBL15110953 | 0.72 | KDM4C (0.34) | CYP11B1CYP11B2APPKDM4EALDH1A1 | |
| SCHEMBL12045426 | 0.71 | HTR6 (0.50) | KDM4EALDH1A1RAB9ASMN1; SMN2HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2802571-A1 | BENZIMIDAZOLE DERIVATIVES AS MCH RECEPTOR ANTAGONISTS | Takeda Pharmaceutical Company Limited (JP) | 2014-11-19 | — | — | EP | disclosed |
| WO-2013105676-A1 | BENZIMIDAZOLE DERIVATIVES AS MCH RECEPTOR ANTAGONISTS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-07-18 | — | — | WO | disclosed |