Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4399691 | 0.80 | PIK3CD (0.37) | PIK3CDCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL9962295 | 0.77 | HTR2B (0.40) | PIK3CDCHRM2CHRM4CHRM5CHRM1 | |
| Hydrochloric Acid SCHEMBL20986770 | 0.74 | HTR6 (0.40) | PIK3CDCHRM2CHRM4CHRM5CHRM1 | |
| Hydrochloric Acid SCHEMBL20986772 | 0.74 | HTR6 (0.40) | PIK3CDCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL15199073 | 0.73 | MEN1 (0.35) | MEN1KMT2AHSD11B1PKM | |
| SCHEMBL7516937 | 0.71 | MEN1 (0.37) | MEN1KMT2AHSD11B1 | |
| SCHEMBL16560462 | 0.71 | HSD11B1 (0.46) | MEN1KMT2AHSD11B1 | |
| SCHEMBL13722579 | 0.71 | NOS1 (0.36) | KMT2ALMNA | |
| SCHEMBL11353898 | 0.70 | TSHR (0.43) | PIK3CDCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL6715928 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150072993-A1 | Parasiticidal Dihydroisoxazole Compounds | JPMORGAN CHASE BANK, N.A., AS SUCCESSOR COLLATERAL AGENT | 2015-03-12 | — | — | US | disclosed |
| US-8889710-B2 | Parasiticidal dihydroisoxazole compounds | ELI LILLY AND COMPANY (US) | 2014-11-18 | — | — | US | disclosed |
| US-20140107149-A1 | PARASITICIDAL DIHYDROISOXAZOLE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2014-04-17 | — | — | US | disclosed |
| US-8648081-B2 | Parasiticidal dihydroisoxazole compounds | ELI LILLY AND COMPANY (US) | 2014-02-11 | — | — | US | disclosed |
| US-20130217699-A1 | PARASITICIDAL DIHYDROISOXAZOLE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2013-08-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140107149-A1 | PARASITICIDAL DIHYDROISOXAZOLE COMPOUNDS | DHODH, DDT, CYP51A1 | PIK3CD 2696/4885MEN1 3118/4885KMT2A 2269/4885 |
| US-20130217699-A1 | PARASITICIDAL DIHYDROISOXAZOLE COMPOUNDS | DHODH, DDT, CYP51A1 | PIK3CD 2553/4885MEN1 3211/4885KMT2A 2424/4885 |
| US-20150072993-A1 | Parasiticidal Dihydroisoxazole Compounds | DHODH, DDT, CYP51A1 | PIK3CD 2696/4885MEN1 3118/4885KMT2A 2269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.