Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | GPR3 | P46089 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL1863432 | 0.88 | MAPT (0.44) | MAPTMAPK1GPR3ALDH1A1CYP1A2 | |
| SCHEMBL5260413 | 0.86 | MAPT (0.45) | MAPTMAPK1GPR3ALDH1A1CYP1A2 | |
| Bromide SCHEMBL1867530 | 0.82 | RAB9A (0.42) | MAPTALDH1A1GAAMEN1KMT2A | |
| Bromide SCHEMBL1868452 | 0.82 | KDM4E (0.38) | MAPTGPR3ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL5260851 | 0.80 | RAB9A (0.43) | MAPTALDH1A1GAAMEN1KMT2A | |
| SCHEMBL5258131 | 0.80 | KDM4E (0.39) | MAPTGPR3ALDH1A1CYP1A2CYP3A4 | |
| Bromide SCHEMBL1862498 | 0.73 | GPR3 (0.37) | GPR3ALDH1A1CYP1A2CYP3A4ALOX15 | |
| Bromide SCHEMBL1861609 | 0.72 | GPR3 (0.37) | MAPTMAPK1GPR3ALDH1A1CYP1A2 | |
| Bromide SCHEMBL1862922 | 0.72 | GPR3 (0.39) | GPR3ALDH1A1CYP1A2CYP3A4ALOX15 | |
| SCHEMBL5259651 | 0.71 | GPR3 (0.38) | GPR3ALDH1A1CYP1A2CYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2814611-B1 | APPARATUS AND METHODS FOR THE PREPARATION OF REACTION VESSELS WITH A 3D-PRINTER | UNIV GLASGOW COURT (GB) | 2020-06-17 | — | — | EP | disclosed |
| US-9643152-B2 | Methods for the preparation of reaction vessels | THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW (GB) | 2017-05-09 | — | — | US | disclosed |
| US-20150010461-A1 | APPARATUS AND METHODS FOR THE PREPARATION OF REACTION VESSELS | Deepmatter Ltd. (GB) | 2015-01-08 | — | — | US | disclosed |
| EP-2814611-A1 | APPARATUS AND METHODS FOR THE PREPARATION OF REACTION VESSELS WITH A 3D -PRINTER | THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW (GB) | 2014-12-24 | — | — | EP | disclosed |
| WO-2013121230-A1 | APPARATUS AND METHODS FOR THE PREPARATION OF REACTION VESSELS WITH A 3D -PRINTER | THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW (GB) | 2013-08-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150010461-A1 | APPARATUS AND METHODS FOR THE PREPARATION OF REACTION VESSELS | FLT4, HTR3D, PTGIS | MAPT 3166/4885MAPK1 2942/4885GPR3 887/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.