Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | CASP1 | P29466 | 2/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15201246 | 0.80 | KMT2A (0.43) | ABL1BCRMEN1KMT2ALCK | |
| SCHEMBL15201255 | 0.80 | ALDH1A1 (0.56) | MEN1KMT2AALDH1A1CYP3A4TSHR | |
| SCHEMBL15201247 | 0.74 | KMT2A (0.68) | MEN1KMT2AALDH1A1TSHRMAPK1 | |
| SCHEMBL15201250 | 0.71 | ABL1 (0.45) | ABL1BCRMEN1KMT2ALCK | |
| SCHEMBL9206595 | 0.69 | ALDH1A1 (0.37) | ABL1BCRMEN1KMT2ALCK | |
| SCHEMBL19957013 | 0.69 | — | — | |
| SCHEMBL22725706 | 0.65 | GPR84 (0.37) | CYP3A4 | |
| SCHEMBL26643751 | 0.65 | GRM5 (0.41) | ALDH1A1MAPK1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL24011026 | 0.64 | RAD52 (0.55) | ABL1BCRMEN1KMT2ALCK | |
| SCHEMBL2616948 | 0.64 | ABL1 (0.59) | ABL1BCRMEN1KMT2ALCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013120852-A1 | INTERMEDIATES FOR A NOVEL PROCESS OF PREPARING IMATINIB AND RELATED TYROSINE KINASE INHIBITORS | GRINDEKS, A JOINT STOCK COMPANY (LV) | 2013-08-22 | — | — | WO | claimed |
| WO-2013120852-A1 | INTERMEDIATES FOR A NOVEL PROCESS OF PREPARING IMATINIB AND RELATED TYROSINE KINASE INHIBITORS | GRINDEKS, A JOINT STOCK COMPANY (LV) | 2013-08-22 | — | — | WO | disclosed |