Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 6/20 | 0.37 |
| ▸ | MEN1 | O00255 | 6/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ALDH2 | P05091 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15211452 | 0.84 | KDM4E (0.41) | MAPTKDM4ERAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL15211621 | 0.81 | FFAR1 (0.56) | MAPTRAB9ASMN1; SMN2PPARDPPARA | |
| SCHEMBL17431516 | 0.80 | PPARD (0.38) | MAPTKDM4EALDH1A1PPARDPPARA | |
| SCHEMBL17444921 | 0.80 | RAB9A (0.48) | MAPTKDM4ERAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL15211482 | 0.79 | PPARD (0.38) | MAPTKDM4ERAB9AALDH1A1NPC1 | |
| SCHEMBL15211199 | 0.76 | NPC1 (0.51) | MAPTKDM4ERAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL5502413 | 0.75 | KDM4E (0.59) | MAPTKDM4ERAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL3921973 | 0.73 | SMN1; SMN2 (0.53) | MAPTKDM4ERAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL15211619 | 0.72 | POLB (0.52) | MAPTKDM4ERAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL437186 | 0.70 | KMT2A (0.51) | MAPTKDM4ERAB9AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2838891-A1 | AROMATIC RING COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2015-02-25 | — | — | EP | disclosed |
| WO-2013125732-A1 | AROMATIC RING COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-08-29 | — | — | WO | disclosed |