Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.49 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.49 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.49 |
| ▸ | XDH | P47989 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5502413 | 0.91 | KDM4E (0.59) | SMN1; SMN2LMNAALDH1A1KDM4ETP53 | |
| SCHEMBL15211199 | 0.86 | NPC1 (0.51) | SMN1; SMN2LMNAALDH1A1KDM4ETP53 | |
| SCHEMBL437186 | 0.81 | KMT2A (0.51) | SMN1; SMN2LMNAALDH1A1KDM4ETP53 | |
| SCHEMBL12099914 | 0.81 | MAPT (0.51) | SMN1; SMN2LMNAALDH1A1KDM4ECYP3A4 | |
| SCHEMBL31493875 | 0.80 | ABCB11 (0.48) | SMN1; SMN2LMNAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL12164332 | 0.80 | ABCB11 (0.48) | SMN1; SMN2LMNAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL15897821 | 0.80 | ALDH1A1 (0.46) | SMN1; SMN2LMNAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL12687295 | 0.80 | KDM4E (0.42) | SMN1; SMN2LMNAALDH1A1KDM4ETP53 | |
| SCHEMBL18550763 | 0.80 | POLB (0.69) | SMN1; SMN2LMNAALDH1A1KDM4ECYP3A4 | |
| SCHEMBL246219 | 0.79 | KDM4E (0.62) | SMN1; SMN2LMNAALDH1A1KDM4ECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112955142-A | Functionalized heterocyclic compounds as antiviral agents | 英安塔制药有限公司 | 2021-06-11 | — | — | CN | disclosed |
| EP-2248812-B1 | FUSED CYCLIC COMPOUNDS AS GPR40 RECEPTOR MODULATORS | TAKEDA PHARMACEUTICAL (JP) | 2013-12-25 | — | — | EP | disclosed |
| EP-2041123-A2 | FUSED CYCLIC COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008001931-A2 | FUSED CYCLIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-01-03 | — | — | WO | disclosed |