Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.57 |
| ▸ | CDK4 | P11802 | 6/20 | 0.56 |
| ▸ | CCND1 | P24385 | 6/20 | 0.56 |
| ▸ | CCND2 | P30279 | 6/20 | 0.56 |
| ▸ | CCND3 | P30281 | 6/20 | 0.56 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.56 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.56 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.56 |
| ▸ | CDK2 | P24941 | 3/20 | 0.56 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.56 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.56 |
| ▸ | CDK1 | P06493 | 2/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.56 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.56 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.56 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.56 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.56 |
| ▸ | JAK3 | P52333 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29813554 | 0.85 | EGFR (0.62) | EGFRCDK4CCND1CCND2CCND3 | |
| SCHEMBL26061436 | 0.77 | JAK2 (0.58) | EGFRCDK4CCND1CCND2CCND3 | |
| SCHEMBL17296027 | 0.77 | WEE1 (0.58) | EGFRCDK4CCND1CCND2CCND3 | |
| SCHEMBL29847961 | 0.77 | EGFR (0.58) | EGFRCDK4CCND1CCND2CCND3 | |
| SCHEMBL16513792 | 0.77 | EGFR (0.58) | EGFRCDK4CCND1CCND2CCND3 | |
| SCHEMBL10346428 | 0.77 | CDK4 (0.61) | EGFRCDK4CCND1CCND2CCND3 | |
| SCHEMBL15212246 | 0.77 | CSF1R (0.55) | EGFRCDK4CCND1CCND2CCND3 | |
| SCHEMBL3583145 | 0.76 | AURKA (0.64) | EGFRCDK4CCND1CCND2CCND3 | |
| SCHEMBL3972215 | 0.76 | CDK4 (0.65) | EGFRCDK4CCND1CCND2CCND3 | |
| SCHEMBL26061435 | 0.76 | ALK (0.64) | CDK4CCND1CCNE1CDK2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981886-B1 | 7H-PYRIDO[3,4-D]PYRIMIDIN-8-ONES, THEIR MANUFACTURE AND USE AS PROTEIN KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-08-12 | — | — | EP | disclosed |