Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | ALPL | P05186 | 6/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | CASP1 | P29466 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15212753 | 0.91 | ALPL (0.59) | ALDH1A1MAPTGAAKMT2AMEN1 | |
| SCHEMBL28891626 | 0.85 | GLO1 (0.60) | GAAKMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL28417672 | 0.82 | GLO1 (0.59) | ALDH1A1MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL15212730 | 0.82 | ALPL (0.61) | ALDH1A1MAPTGAAKMT2AMEN1 | |
| SCHEMBL15212816 | 0.82 | ALDH1A1 (0.55) | ALDH1A1MAPTGAAKMT2AMEN1 | |
| SCHEMBL15212750 | 0.81 | ALDH1A1 (0.54) | ALDH1A1MAPTGAAKMT2AMEN1 | |
| SCHEMBL15212768 | 0.81 | ALPL (0.60) | ALDH1A1MAPTGAAKMT2AMEN1 | |
| SCHEMBL28418113 | 0.80 | GLO1 (0.59) | ALDH1A1KMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL3447043 | 0.78 | ALDH1A1 (0.71) | ALDH1A1MAPTGAAKMT2AMEN1 | |
| SCHEMBL15212074 | 0.78 | ALPL (0.64) | ALDH1A1MAPTGAAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2817292-A1 | SULFONAMIDE COMPOUNDS AND USES AS TNAP INHIBITORS | Sanford-Burnham Medical Research Institute (US) | 2014-12-31 | — | — | EP | disclosed |
| WO-2013126608-A1 | SULFONAMIDE COMPOUNDS AND USES AS TNAP INHIBITORS | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2013-08-29 | — | — | WO | disclosed |